|
type |
Journal Article |
authors |
Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C. |
title |
Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway.
|
journal |
Angew Chem Int Ed Engl |
Activity |
glii |
Family |
glii |
sel |
selected |
ui |
22936680 |
year |
(2012) |
volume |
51 |
number |
40 |
pages |
10064-8 |
| |
abstract |
The elucidation of a key step in the biosynthesis of gliotoxin, the infamous virulence factor of the human pathogen Aspergillus fumigatus, provides insight into the formation of an epidithiol. Isolation of a bis(cysteine) S-conjugate from a ΔgliI mutant and in vitro studies show that GliI concomitantly cleaves two C[BOND]S bonds, along with the formation of ammonia and pyruvate |
last changed |
2014/08/22 09:44 |
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