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B6db references: 22936680

type Journal Article
authors Scharf DH, Chankhamjon P, Scherlach K, Heinekamp T, Roth M, Brakhage AA, Hertweck C.
title Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway.
journal Angew Chem Int Ed Engl
Activity glii
Family glii
sel selected
ui 22936680
year (2012)
volume 51
number 40
pages 10064-8
abstract The elucidation of a key step in the biosynthesis of gliotoxin, the infamous virulence factor of the human pathogen Aspergillus fumigatus, provides insight into the formation of an epidithiol. Isolation of a bis(cysteine) S-conjugate from a ΔgliI mutant and in vitro studies show that GliI concomitantly cleaves two C[BOND]S bonds, along with the formation of ammonia and pyruvate
last changed 2014/08/22 09:44

B6db references