|
type |
Journal Article |
authors |
Zou Y1, Fang Q, Yin H, Liang Z, Kong D, Bai L, Deng Z, Lin S.
|
title |
Stereospecific biosynthesis of β-methyltryptophan from (L)-tryptophan features a stereochemical switch |
journal |
Angew Chem Int Ed Engl |
Activity |
marg |
Family |
marg |
sel |
selected |
ui |
24166888 |
year |
(2013) |
volume |
52 |
number |
49 |
pages |
12951-5 |
| |
abstract |
Make the switch: The three-enzyme cassette MarG/H/I is responsible for stereospecific biosynthesis of β-methyltryptophan from L-tryptophan (1). MarG/I convert 1 into (2S,3R)-β-methyltryptophan, while MarG/I combined with MarH convert 1 into (2S,3S)-β-methyltryptophan. MarH serves as a stereochemical switch by catalyzing the stereoinversion of the β-stereocenter. |
last changed |
2014/08/22 09:12 |
|