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B6db references: 25938369

type Journal Article
authors Allen KD, Miller DV, Rauch BJ, Perona JJ, White RH
title Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea
journal Biochemistry
sel selected
ui 25938369
year (2015)
volume 54
number 20
pages 3129-32
keywords DOI: 10.1021/acs.biochem.5b00118
abstract The biosynthetic route for homocysteine, intermediate in methionine biosynthesis, is unknown in some methanogenic archaea because homologues of the canonical required genes cannot be identified. Here we demonstrate that Methanocaldococcus jannaschii can biosynthesize homocysteine from aspartate semialdehyde and hydrogen sulfide. Additionally, we confirm the genes involved in this new pathway in Methanosarcina acetivorans. A possible series of reactions in which a thioaldehyde is formed and then reduced to a thiol are proposed. This represents a novel route for the biosynthesis of homocysteine and exemplifies unique aspects of sulfur chemistry occurring in prebiotic environments and in early life forms.
last changed 2019/08/28 12:06

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