|
type |
Journal Article |
authors |
Ye Y, Minami A, Igarashi Y, Izumikawa M, Umemura M, Nagano N, Machida M, Kawahara T, Shin-Ya K, Gomi K, Oikawa H. |
title |
Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post‐translationally Modified Peptide Ustiloxin B in Filamentous Fungi |
journal |
Angew Chem Int Ed Engl |
Activity |
ustd |
Family |
ustd |
PLP Fold Type |
1 |
sel |
selected |
ui |
27166860 |
year |
(2016) |
volume |
55 |
number |
28 |
pages |
8072-5 |
| |
keywords |
doi.org/10.1002/ange.201602611 |
abstract |
The biosynthetic machinery of the first fungal ribosomally synthesized and post-translationally modified peptide (RiPP) ustiloxin B was elucidated through a series of gene inactivation and heterologous expression studies. The results confirmed an essential requirement for novel oxidases possessing the DUF3328 motif for macrocyclization, and highly unique side-chain modifications by three oxidases (UstCF1F2) and a pyridoxal 5'-phosphate (PLP)-dependent enzyme (UstD). These findings provide new insight into the expression of the RiPP gene clusters found in various fungi. |
last changed |
2018/11/20 12:59 |
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