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B6db references: 28288097

type Journal Article
authors Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T, Nishiyama M.
title Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces
journal Nat Chem Biol.
Activity vzb9
Family vzb9
PLP Fold Type 1
sel selected
ui 28288097
year (2016)
volume 12
number 11
pages 967-972
keywords DOI: 10.1038/nchembio.2181
abstract Amino-group carrier proteins (AmCPs) mediate the biosynthesis of lysine and arginine in some bacteria and archaea. Here we demonstrate that an uncharacterized AmCP-mediated biosynthetic system functions to biosynthesize the previously uncharacterized and nonproteinogenic amino acid (2S,6R)-diamino-(5R,7)-dihydroxy-heptanoic acid (DADH) in Streptomyces sp. SANK 60404. DADH is incorporated into a novel peptide metabolite, vazabitide A, featuring an azabicyclo-ring structure, by nonribosomal peptide synthetases and successive modification enzymes in this bacterium. As the AmCP-mediated machinery for DADH biosynthesis is widely distributed in bacteria, further analysis of uncharacterized AmCP-containing gene clusters will lead to the discovery of novel bioactive compounds and novel biosynthetic enzymes.
last changed 2018/11/27 16:42

B6db references