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B6db references: 29320746

type Journal Article
authors Luqman A, Nega M, Nguyen MT, Ebner P, Götz F
title SadA-Expressing Staphylococci in the Human Gut Show Increased Cell Adherence and Internalization
journal Cell Rep
sel selected
ui 29320746
year (2018)
volume 22
number 2
pages 535-545
keywords adherence; aromatic amino acid decarboxylase; gut microbiota; internalization; neuromodulator; neurotransmitter; staphylococcus
abstract A subgroup of biogenic amines, the so-called trace amines (TAs), are produced by mammals and bacteria and can act as neuromodulators. In the genus Staphylococcus, certain species are capable of producing TAs through the activity of staphylococcal aromatic amino acid decarboxylase (SadA). SadA decarboxylates aromatic amino acids to produce TAs, as well as dihydroxy phenylalanine and 5-hydroxytryptophan to thus produce the neurotransmitters dopamine and serotonin. SadA-expressing staphylococci were prevalent in the gut of most probands, where they are part of the human intestinal microflora. Furthermore, sadA-expressing staphylococci showed increased adherence to HT-29 cells and 2- to 3-fold increased internalization. Internalization and adherence was also increased in a sadA mutant in the presence of tryptamine. The α2-adrenergic receptor is required for enhanced adherence and internalization. Thus, staphylococci in the gut might contribute to gut activity and intestinal colonization.
last changed 2018/05/18 19:11

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