|
type |
Journal Article |
authors |
Gonzalez-Porque, P.; Strominger, J.L. |
title |
Introducting of the 3-deoxy group in 3,6-dideoxyhexoses: a novel cofactor function for pyridoxamine-5'-phosphate |
journal |
Proc Natl Acad Sci U S A |
Activity |
1.17.1.1 |
sel |
selected |
ui |
4504380 |
year |
(1972) |
volume |
69 |
number |
6 |
pages |
1625-8 |
| |
abstract |
A cofactor needed for the reduction of CDP-4-keto-6-deoxy-D-glucose to CDP-4-keto-3,6-dideoxy D-glucose has been detected and purified. Its spectra in neutral, acid, and basic solutions, its behavior on thin-layer chromatography, and other properties led to its identification as pyridoxamine-5′-phosphate. Moreover, authentic pyridoxamine-5′-phosphate substituted for the purified cofactor with about the same specific activity. Other vitamin B6 derivatives did not stimulate the reaction, and inhibition was observed with some of them. |
last changed |
2009/05/05 11:54 |
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