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B6db references: 7704274

type Journal Article
authors Foglino, M.; Borne, F.; Bally, M.; Ball, G.; Patte, J. C.
title A direct sulfhydrylation pathway is used for methionine biosynthesis in Pseudomonas aeruginosa
journal Microbiology
Activity o.succinylhomoserine.sulfhydrylase
Family o.succinylhomoserine.sulfhydrylase
sel selected
ui 7704274
year (1995)
volume 141
number Pt 2
pages 431-9
keywords Amino Acid Sequence
abstract The relationship between genes and enzymes in the methionine biosynthetic pathway has been studied in Pseudomonas aeruginosa. The first step is catalysed by an O-succinylhomoserine synthase, the product of the metA gene mapped at 20 min on the chromosome. The second step is achieved by direct sulfhydrylation, involving the enzyme encoded by a metZ gene that we have identified and sequenced, located at 40 min. Thus Pseudomonas appears to be the only organism so far described that uses O-succinylhomoserine as substrate for a direct sulfhydrylation. As in yeast, the two transsulfuration pathways between cysteine and homocysteine, with cystathionine as an intermediate, probably exist in parallel in this organism.
last changed 2009/07/10 16:38

B6db references