|
type |
Journal Article |
authors |
Galman,J.L., Slabu,I., Weise,N.J., Iglesias,C., Parmeggiani,F., Lloyd,R.C. and Turner,N.J. |
title |
Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases |
journal |
Green Chem |
Activity |
2.6.1.113 |
Family |
2.6.1.113 |
sel |
selected |
ui |
NOT-in-medline |
year |
(2017) |
volume |
19 |
pages |
361-366 |
| |
keywords |
benzylamines; biocatalysis; green chemistry; protein structure; transaminase |
abstract |
The discovery and characterisation of enzymes with both monoamine and diamine transaminase activity is reported, allowing conversion of a wide range of target ketone substrates with just a small excess of amine donor. The diamine co-substrates (putrescine, cadaverine or spermidine) are bio-derived and the enzyme system results in very little waste, making it a greener strategy for the production of valuable amine fine chemicals and pharmaceuticals. |
last changed |
2019/01/14 13:38 |
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