|
|
1.4.4.2 |
Activity |
1.4.4.2 |
Description |
Glycine dehydrogenase (decarboxylating) |
Notes |
In some organisms, the protein has two distinct subunits. See for example:
gi|14591729|ref|NP_143817.1| glycine dehydrogenase subunit 1 [Pyrococcus horikoshii]
gi|14591728|ref|NP_143816.1| glycine dehydrogenase subunit 2 [Pyrococcus horikoshii]. The two subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence. Only the second subunit, corresponding to the C-terminal half of the multi-domain proteins in known to bind the PLP. |
PDB |
1WYU;4LHD; |
PLP Fold Type |
I |
PLP-dependent Domain |
|
Number of sequences |
31 |
Sequences in seed alignment |
|
Reference sequence |
GCSP_CHICK |
Domain interval |
540-934 |
Catalytic site |
738 K |
| |
References |
Hasse D.; Mikkat S.; Thrun H.A.; Hagemann, M.; Bauwe, H. (2007) Properties of recombinant glycine decarboxylase P- and H-protein subunits from the cyanobacterium Synechocystis sp. strain PCC 6803.
FEBS Lett 581 1297-301. Nakai T, Nakagawa N, Maoka N, Masui R, Kuramitsu S, Kamiya N. (2005) Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia EMBO J 24 1523-1536. Turner, S.R.; Ireland, R.; Rawsthorne, S. (1992) Cloning and characterization of the P subunit of glycine decarboxylase from pea (Pisum sativum) J Biol Chem 267 5355-60. Fujiwara, K.; Okamura-Ikeda, K.; Motokawa, Y. (1987) Amino acid sequence of the phosphopyridoxyl peptide from P-protein of the chicken liver glycine cleavage system Biochem Biophys Res Commun 149 621-7. Articles on 1.4.4.2 |
last changed |
2014/03/04 10:25 |
|