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B6db families: b
Description Serine C-palmitoyltransferase (family b)
Notes This family includes the products LCB2 genes.
Proteins in this family are the water-soluble subunits of eukaryotic serine C-palmitoyl transferases and (contrary to LCB1 proteins - family they bind PLP.
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence LCB2_YEAST
Domain interval 155-515
Catalytic site 366 K
 Han G, Gable K, Yan L, Allen MJ, Wilson WH, Moitra P, Harmon JM, Dunn TM. (2006) Expression of a novel marine viral single-chain serine palmitoyltransferase and construction of yeast and mammalian single-chain chimera J Biol Chem 281 39935-42.

 Bae, J.H.; Sohn, J.H.; Park, C.S.; Rhee, J.S.; Choi, E.S. (2003) Integrative transformation system for the metabolic engineering of the sphingoid base-producing yeast Pichia ciferrii Appl Environ Microbiol 69 812-9.

 Tamura, K.; Nishiura, H.; Mori, J.; Imai, H. (2000) Cloning and characterization of a cDNA encoding serine palmitoyltransferase in Arabidopsis thaliana Biochem Soc Trans 28 745-7.

 Hanada, K.; Hara, T.; Nishijima, M.; Kuge, O.; Dickson, R.C.; Nagiec, M.M. (1997) A mammalian homolog of the yeast LCB1 encodes a component of serine palmitoyltransferase, the enzyme catalyzing the first step in sphingolipid synthesis J Biol Chem 272 32108-14.

 Weiss, B.; Stoffel, W. (1997) Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis Eur J Biochem 249 239-47.

 Nagiec, M.M.; Baltisberger, J.A.; Wells, G.B.; Lester, R.L.; Dickson, R.C. (1994) The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Proc Natl Acad Sci U S A 91 7899-902.

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last changed 2008/05/20 12:02

B6db families