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|
2.5.1.134 |
Activity |
2.5.1.134 |
Description |
Cystathionine β-synthase (O-acetyl-L-serine) |
Notes |
Family based on the functionally validated sequence from B. anthracis, related to standard CBS and to cysteine synthases. A distinctive residue of this family is Glu228 (in the B anthracis sequence BAR74765) which is necessary
for generating H2S. |
PDB |
5DX5;5B1H;5HBG; |
PLP Fold Type |
II |
PLP-dependent Domain |
|
Number of sequences |
13 |
Sequences in seed alignment |
|
Reference sequence |
BAR74765 |
Domain interval |
15-300 |
Catalytic site |
52 K |
| |
References |
Devi S, Tarique KF, Ali MF, Abdul Rehman SAX, Gourinath S (2019) Identification and characterisation of Helicobacter pylori O-acetylserine-dependent cystathionine β-synthase, a distinct member of the PLP-II family Mol Microbiol 112 718-739. Devi S, Abdul Rehman SA, Tarique KF, Gourinath S (2017) Structural characterization and functional analysis of cystathionine β-synthase: an enzyme involved in the reverse transsulfuration pathway of Bacillus anthracis FEBS J 284 3862-3880. Matoba Y, Yoshida T, Izuhara-Kihara H, Noda M, Sugiyama M
(2017) Crystallographic and mutational analyses of cystathionine β-synthase in the H2 S-synthetic gene cluster in Lactobacillus plantarum
Protein Sci 26 763-783. Hullo MF, Auger S, Soutourina O, Barzu O, Yvon M, Danchin A, Martin-Verstraete I (2007) Conversion of methionine to cysteine in Bacillus subtilis and its regulation J Bacteriol 189 187-97. Articles on 2.5.1.134 |
last changed |
2019/06/03 10:58 |
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