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B6db families: 2.5.1.134

2.5.1.134
Activity 2.5.1.134
Description Cystathionine β-synthase (O-acetyl-L-serine)
Notes Family based on the functionally validated sequence from B. anthracis, related to standard CBS and to cysteine synthases.

A distinctive residue of this family is Glu228 (in the B anthracis sequence BAR74765) which is necessary for generating H2S.

PDB 5DX5;5B1H;5HBG;
PLP Fold Type II
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type II

Reference sequence BAR74765
Domain interval 15-300
Catalytic site 52 K
 
References
 Devi S, Tarique KF, Ali MF, Abdul Rehman SAX, Gourinath S (2019) Identification and characterisation of Helicobacter pylori O-acetylserine-dependent cystathionine β-synthase, a distinct member of the PLP-II family Mol Microbiol 112 718-739.

 Devi S, Abdul Rehman SA, Tarique KF, Gourinath S (2017) Structural characterization and functional analysis of cystathionine β-synthase: an enzyme involved in the reverse transsulfuration pathway of Bacillus anthracis FEBS J 284 3862-3880.

 Matoba Y, Yoshida T, Izuhara-Kihara H, Noda M, Sugiyama M (2017) Crystallographic and mutational analyses of cystathionine β-synthase in the H2 S-synthetic gene cluster in Lactobacillus plantarum Protein Sci 26 763-783.

 Hullo MF, Auger S, Soutourina O, Barzu O, Yvon M, Danchin A, Martin-Verstraete I (2007) Conversion of methionine to cysteine in Bacillus subtilis and its regulation J Bacteriol 189 187-97.

Articles on 2.5.1.134
last changed 2019/06/03 10:58

B6db families