B6db families : 2_5_1_48

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2.5.1.48 b

Activity

2.5.1.48

Description

Cystathionine gamma-synthase (family b)

Notes

While subfamily a includes a group of enzymes with cystathionine gamma-synthase activity that are found in gram-negative bacteria, subfamily 2.5.1.48b encompasses sequences from plants (plastidial proteins) and cyanobacteria.

PDB

1QGN;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria	ZP_00020648 (Chloroflexus aurantiacus); NP_867259 (Pirellula sp.);
Viridiplantae	AAK50405 (Oryza sativa); AAB61348 (Zea mays); AAR92031 (Lycopersicon esculentum); AF141602_1 (Glycine max); T12288 (Mesembryanthemum crystallinum); METB_ARATH (Arabidopsis thaliana); CAB57356 (Fragaria vesca); 1QGNA (Nicotiana tabacum);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

1QGNA

Domain interval

58-443

Catalytic site

261 K

References

Steegborn, C.; Messerschmidt, A.; Laber, B.; Streber, W.; Huber, R.; Clausen, T. (1999) The crystal structure of cystathionine gamma-synthase from Nicotiana tabacum reveals its substrate and reaction specificity J Mol Biol 290 983-96..

Ravanel, S.; Gakiere, B.; Job, D.; Douce, R. (1998) Cystathionine gamma-synthase from Arabidopsis thaliana: purification and biochemical characterization of the recombinant enzyme overexpressed in Escherichia coli Biochem J 331 639-48..

Articles on 2.5.1.48.b

last changed

2007/10/19 19:05