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B6db families: 2.5.1.49

2.5.1.49
Activity 2.5.1.49
Description O-acetylhomoserine (thiol)-lyase.
Notes Formerly 4.2.99.10
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
23
Sequences in seed alignment
ArchaeaNP_617614.1 (Methanosarcina acetivorans str. C2A);
BacteriaBAB68505.1 (Thermus thermophilus); ZP_00119048 (Cytophaga hutchinsonii); NP_540083.1 (Brucella melitensis); ZP_00121486 (Bifidobacterium longum DJO10A); CAA71732 (Leptospira meyeri); ZP_00107219 (Nostoc punctiforme); NP_464123.1 (Listeria monocytogenes EGD-e); BAB68505 (Thermus thermophilus); NP_349387.1 (Clostridium acetobutylicum); NP_531944.1 (Agrobacterium tumefaciens str. C58 (U. Washington)); NP_623710.1 (Thermoanaerobacter tengcongensis); NP_385354.1 (Sinorhizobium meliloti); ZP_00115203 (Synechococcus sp. WH 8102); ZP_00082400 (Geobacter metallireducens); NP_661504.1 (Chlorobium tepidum TLS); NP_228690.1 (Thermotoga maritima);
FungiAAF01452 (Candida albicans); CYSD_SCHPO (Schizosaccharomyces pombe); MT17_KLULA (Kluyveromyces lactis); MT17_YEAST (Saccharomyces cerevisiae); CYSD_EMENI (Emericella nidulans); CAB99179 (Neurospora crassa);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence CYSD_SCHPO
Domain interval 9-427
Catalytic site 210 K
 
References
 Shimizu H, Yamagata S, Masui R, Inoue Y, Shibata T, Yokoyama S, Kuramitsu S, Iwama T. (2001) Cloning and overexpression of the oah1 gene encoding O-acetyl-L-homoserine sulfhydrylase of Thermus thermophilus HB8 and characterization of the gene product Biochim Biophys Acta 1549 1-72.

 Yamagata, S.; Ichioka, K.; Goto, K.; Mizuno, Y; Iwama, T. (2001) Occurrence of transsulfuration in synthesis of L-homocysteine in an extremely thermophilic bacterium, Thermus thermophilus HB8 J Bacteriol 183 2086-92.

 Bourhy, P.; Martel, A.; Margarita, D.; Saint Girons, I.; Belfaiza, J. (1997) Homoserine O-acetyltransferase, involved in the Leptospira meyeri methionine biosynthetic pathway, is not feedback inhibited J Bacteriol 179 4396-4398.

 Yamagata, S.; Isaji, M.; Nakamura, K.; Fujisaki, S.; Doi, K.; Bawden, S.; D'Andrea, R. (1994) Overexpression of the Saccharomyces cerevisiae MET17/MET25 gene in Escherichia coli and comparative characterization of the product with O-acetylserine.O-acetylhomoserine sulfhydrylase of the yeast Appl Microbiol Biotechnol 42 92-99.

 Brzywczy, J.; Yamagata, S.; Paszewski, A. (1993) Comparative studies on O-acetylhomoserine sulfhydrylase: physiological role and characterization of the Aspergillus nidulans enzyme Acta Biochim Pol 40 421-8.

Articles on 2.5.1.49
last changed 2007/09/08 13:07

B6db families