|
|
| |
2.6.1.103 |
| Activity |
2.6.1.103 |
| Description |
(S)-3,5-dihydroxyphenylglycine transaminase |
| Notes |
The family includes the bacterial sequences most similar to the validated gene products from Streptomyces lavendulae, S. pactum and Amycolatopsis orientalis.
More distantly related sequences also occur in Nocardia (NocG, in the gene cluster for the biosynthesis of Nocardicin A) and other bacteria, but they have not been included here. |
| PLP Fold Type |
I |
| PLP-dependent Domain |
|
| Reference sequence |
CAA11790 |
| Domain interval |
65-425 |
| Catalytic site |
266 K |
| | |
|---|
| References |
Tan B, Zhang Q, Zhu Y, Jin H, Zhang L, Chen S, Zhang C (2020) Deciphering Biosynthetic Enzymes Leading to 4-Chloro-6-Methyl-5,7-Dihydroxyphenylglycine, a Non-Proteinogenic Amino Acid in Totopotensamides
ACS Chem Biol in press. Chiu, H. T.; Hubbard, B. K.; Shah, A. N.; Eide, J.; Fredenburg, R. A.; Walsh, C. T.; Khosla, C. (2001) Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster Proc Natl Acad Sci U S A 98 8548-53. Pfeifer V, Nicholson GJ, Ries J, Recktenwald J, Schefer AB, Shawky RM, Schröder J, Wohlleben W, Pelzer S (2001) A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine J Biol Chem 276 38370-7. Sandercock, A.M., Charles, E.H., Scaife, W., Kirkpatrick, P.N., O'Brien, S.W., Papageorgiou, E.A., Spencer, J.B., Williams, D.H. (2001) Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin Chem Commun 2001 1252-1253. Hubbard BK, Thomas MG, Walsh CT. (2000) Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics
Chem Biol 7 931-42. |
| last changed |
2020/03/03 16:48 |
|
Browse:
Analyse:
Find: