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B6db families:
Description (S)-3,5-dihydroxyphenylglycine transaminase
Notes The family includes the bacterial sequences most similar to the validated gene products from Streptomyces lavendulae, S. pactum and Amycolatopsis orientalis.
More distantly related sequences also occur in Nocardia (NocG, in the gene cluster for the biosynthesis of Nocardicin A) and other bacteria, but they have not been included here.
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 14
Sequences in seed alignment
BacteriaWP_003980917 (Kitasatospora aureofaciens); SCE53511 (Streptomyces sp. SolWspMP-5a-2); WP_050364102 (Streptomyces fradiae); WP_149564538 (Streptomyces cacaoi); WP_030676815 (Streptomyces rimosus); WP_060954310 (Streptomyces hygroscopicus); CAA11790 (Amycolatopsis orientalis); AIG79226 (Amycolatopsis japonica); AAK81836 (Streptomyces lavendulae); CAC48367 (Amycolatopsis balhimycina); WP_078643503 (Streptomyces varsoviensis); CAD91232 (Nonomuraea gerenzanensis); ATL73043 (Streptomyces pactum); AQZ69233 (Nonomuraea sp. ATCC 55076);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence CAA11790
Domain interval 65-425
Catalytic site 266 K
 Tan B, Zhang Q, Zhu Y, Jin H, Zhang L, Chen S, Zhang C (2020) Deciphering Biosynthetic Enzymes Leading to 4-Chloro-6-Methyl-5,7-Dihydroxyphenylglycine, a Non-Proteinogenic Amino Acid in Totopotensamides ACS Chem Biol in press.

 Chiu, H. T.; Hubbard, B. K.; Shah, A. N.; Eide, J.; Fredenburg, R. A.; Walsh, C. T.; Khosla, C. (2001) Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster Proc Natl Acad Sci U S A 98 8548-53.

 Pfeifer V, Nicholson GJ, Ries J, Recktenwald J, Schefer AB, Shawky RM, Schröder J, Wohlleben W, Pelzer S (2001) A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine J Biol Chem 276 38370-7.

 Sandercock, A.M., Charles, E.H., Scaife, W., Kirkpatrick, P.N., O'Brien, S.W., Papageorgiou, E.A., Spencer, J.B., Williams, D.H. (2001) Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin Chem Commun 2001 1252-1253.

 Hubbard BK, Thomas MG, Walsh CT. (2000) Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics Chem Biol 7 931-42.

Articles on
last changed 2020/03/03 16:48

B6db families