B6db families : 2_6_1

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2.6.1.103

Activity

2.6.1.103

Description

(S)-3,5-dihydroxyphenylglycine transaminase

Notes

The family includes the bacterial sequences most similar to the validated gene products from Streptomyces lavendulae, S. pactum and Amycolatopsis orientalis.
More distantly related sequences also occur in Nocardia (NocG, in the gene cluster for the biosynthesis of Nocardicin A) and other bacteria, but they have not been included here.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

WP_003980917 (Kitasatospora aureofaciens); SCE53511 (Streptomyces sp. SolWspMP-5a-2); WP_050364102 (Streptomyces fradiae); WP_149564538 (Streptomyces cacaoi); WP_030676815 (Streptomyces rimosus); WP_060954310 (Streptomyces hygroscopicus); CAA11790 (Amycolatopsis orientalis); AIG79226 (Amycolatopsis japonica); AAK81836 (Streptomyces lavendulae); CAC48367 (Amycolatopsis balhimycina); WP_078643503 (Streptomyces varsoviensis); CAD91232 (Nonomuraea gerenzanensis); ATL73043 (Streptomyces pactum); AQZ69233 (Nonomuraea sp. ATCC 55076);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

CAA11790

Domain interval

65-425

Catalytic site

266 K

References

Tan B, Zhang Q, Zhu Y, Jin H, Zhang L, Chen S, Zhang C (2020) Deciphering Biosynthetic Enzymes Leading to 4-Chloro-6-Methyl-5,7-Dihydroxyphenylglycine, a Non-Proteinogenic Amino Acid in Totopotensamides ACS Chem Biol in press.

Chiu, H. T.; Hubbard, B. K.; Shah, A. N.; Eide, J.; Fredenburg, R. A.; Walsh, C. T.; Khosla, C. (2001) Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster Proc Natl Acad Sci U S A 98 8548-53.

Pfeifer V, Nicholson GJ, Ries J, Recktenwald J, Schefer AB, Shawky RM, Schröder J, Wohlleben W, Pelzer S (2001) A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine J Biol Chem 276 38370-7.

Sandercock, A.M., Charles, E.H., Scaife, W., Kirkpatrick, P.N., O'Brien, S.W., Papageorgiou, E.A., Spencer, J.B., Williams, D.H. (2001) Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin Chem Commun 2001 1252-1253.

Hubbard BK, Thomas MG, Walsh CT. (2000) Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics Chem Biol 7 931-42.

Articles on 2.6.1.103

last changed

2020/03/03 16:48