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B6db families: 2.6.1.105

2.6.1.105
Activity 2.6.1.105
Description Lysine--8-amino-7-oxononanoate transaminase
Notes Family based on the validat3ed sequence from Bacillus subtilis. Enzymes very similar to those in family 2.6.1.62, but distinct based on the fact that use L-lysine as the amino group donor.
PDB 3DOD;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence BAC03240
Domain interval 29-380
Catalytic site 280 K
 
References
 Dey, S.; Lane, J.M.; Lee, R.E.; Rubin, E.J.; Sacchettini, J.C. (2010) Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase Biochemistry 49 6746-60.

 Van Arsdell, SW.; Perkins, J.B.; Yocum, R.R.; Luan, L.; Howitt, C.L.; Prasad Chatterjee, N.; Pero, J.G. (2005) Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction Biotechnol Bioeng 91 75-83.

Articles on 2.6.1.105
last changed 2017/09/05 10:02

B6db families