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B6db families: 2.6.1.18.a

2.6.1.18 a
Activity 2.6.1.18
Description Beta-alanine--pyruvate aminotransferase (family a)
Notes The bacterial enzymes in this family are very similar to plant gamma-aminobutyrate--pyruvate aminotransferase (2.6.1.96, distinct from EC 2.6.1.19, which uses preferentially 2-oxoglutarate as an amino group acceptor) and to 2.6.1.113 (putrescine--pyruvate aminotransferase).

A sequence of "beta-alanine-pyruvate aminotransferase from rat" (accession n. BAA19549) is present in NCBI, but the sequence is essentially identical to that of mitochondrial alanine-glyoxylate aminotransferase 2 (2.1.6.44).

PDB 3A8U;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence OAPT_PSEPU
Domain interval 35-390
Catalytic site 288 K
 
References
 Wilding M, Peat TS, Newman J, Scott C (2016) A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC Appl Environ Microbiol 82 3846-56.

 Yun, H.; Lim, S.; Cho, B.K.; Kim, B.G. (2004) omega-Amino acid:pyruvate transaminase from Alcaligenes denitrificans Y2k-2: a new catalyst for kinetic resolution of beta-amino acids and amines Appl Environ Microbiol 70 2529-34.

 Yonaha, K.; Nishie, M.; Aibara, S. (1992) The primary structure of omega-amino acid:pyruvate aminotransferase J Biol Chem 267 12506-10.

 Watanabe, N. Sakabe, K. Sakabe, N. Higashi, T. Sasaki, K. Aibara, S. Morita, Y. Yonaha, K. Toyama, S. Fukutani, H. (1989) Crystal structure analysis of omega-amino acid:pyruvate aminotransferase with a newly developed Weissenberg camera and an imaging plate using synchrotron radiation J Biochem 105 1-3.

Articles on 2.6.1.18.a
last changed 2020/02/17 12:14

B6db families