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B6db families: a
Description 4-aminobutyrate aminotransferase (family a)
Notes This subfamily includes metazoan and fungal enzymes. The enzyme from rat liver seems to be identical to (S)-3-amino-2-methylpropanoate aminotransferase (
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 14
Sequences in seed alignment
FungiABF58894 (Lachancea kluyveri); GATA_YEAST (Saccharomyces cerevisiae); GATA_SCHPO (Schizosaccharomyces pombe); GATA_EMENI (Emericella nidulans); GATA_USTMA (Ustilago maydis); AAG17665 (Cladosporium fulvum);
MetazoaGABT_RAT (Rattus norvegicus); GABT_BOVIN (Bos taurus); GABT_HUMAN (Homo sapiens); AAH60364 (Xenopus laevis); AAF49081 (Drosophila melanogaster); XP_308791 (Anopheles gambiae); GABT_PIG (Sus scrofa); GABT_CAEEL (Caenorhabditis elegans);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence GABT_RAT
Domain interval 76-446
Catalytic site 357 K
 Andersen G, Andersen B, Dobritzsch D, Schnackerz KD, Piskur J. (2007) A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast FEBS J 274 1804-17.

 Jeon, S.G.; Bahn, J.H.; Jang, J.S.; Jang, S.H.; Lee, B.R.; Lee, K.S.; Park, J.; Kang, T.C.; Won, M.H.; Kim, H.B.; Kwo, O.S.; Cho, S.W.; Choi, S.Y. (2001) Molecular cloning and functional expression of bovine brain GABA transaminase Mol Cells 12 91-6.

 Storici, P.; Capitani, G.; De Biase, D.; Moser, M.; John, R. A.; Jansonius, J. N.; Schirmer, T. (1999) Crystal structure of GABA-aminotransferase, a target for antiepileptic drug therapy Biochemistry 38 8628-34.

 Medina-Kauwe, L.K.; Tillakaratne, N.J.; Wu, J.Y.; Tobin, A.J. (1994) A rat brain cDNA encodes enzymatically active GABA transaminase and provides a molecular probe for GABA-catabolizing cells J Neurochem 62 1267-75.

 Tamaki, N.; Fujimoto, S.; Mizota, C.; Kikugawa, M. (1987) Identity of beta-alanine-oxo-glutarate aminotransferase and L-beta- aminoisobutyrate aminotransferase in rat liver Biochim Biophys Acta 925 238-40.

Articles on
last changed 2007/10/30 14:51

B6db families