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B6db families: 2.6.1.2.a

2.6.1.2 a
Activity 2.6.1.2
Description Alanine aminotransferase (family a)
Notes This family includes archaeal enzymes, similar to the prototypical alanine aminotransferase from Pyrococcus furiosus, and enzymes from bacteria, like the rather broad-specificity AlaT from C. glutamicum and the preliminarly characterized AlaA from E. coli.
PDB 1XI9;4CVQ;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
30
Sequences in seed alignment
ArchaeaBAD85283 (Thermococcus kodakarensis KOD1); WP_026068856 (Methanomassiliicoccus luminyensis); WP_075055666 (Nitrososphaera viennensis); ABK78579 (Cenarchaeum symbiosum A); WP_014962445 (Nitrosopumilus sp. SJ); NP_143210 (Pyrococcus horikoshii); WP_068324275 (Pyrococcus kukulkanii); WP_015282668 (Aciduliprofundum sp. MAR08-339); ABL77437 (Thermofilum pendens Hrk 5); AAG00592 (Thermococcus sp. TK1); AAF65616 (Pyrococcus furiosus);
BacteriaCJK49519 (Streptococcus pneumoniae); KUJ69475 (Streptomyces albus subsp. albus); WP_037104350 (Rhodococcus fascians); SHH00506 (Streptoalloteichus hindustanus); NP_602037 (Corynebacterium glutamicum ATCC 13032); KJY85576 (Pseudoalteromonas piscicida); WP_020103956 (Mycobacterium mucogenicum); SNT17113 (Actinomadura meyerae); WP_094336549 (Alkalispirochaeta americana); WP_029152975 (Microbacterium gubbeenense); WP_086591964 (Corynebacterium pseudotuberculosis); CCP43067 (Mycobacterium tuberculosis H37Rv); WP_013494117 (Intrasporangium calvum); WP_029901133 (Nocardia brasiliensis); WP_038063585 (Thermodesulfobacterium commune); WP_030198931 (Corynebacterium variabile); WP_001179458 (Vibrio cholerae); WP_010906454 (Pasteurella multocida); ALAA_ECOLI (Escherichia coli);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence AAF65616
Domain interval 30-388
Catalytic site 237 K
 
References
 Jansen RS, Mandyoli L, Hughes R, Wakabayashi S, Pinkham JT, Selbach B, Guinn KM, Rubin EJ, Sacchettini JC, Rhee KY (2020) Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis Nat Commun 11 1960.

 Peña-Soler E, Fernandez FJ, López-Estepa M, Garces F, Richardson AJ, Quintana JF, Rudd KE, Coll M, Vega MC (2014) Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli PLoS One 9 e102139.

 Kim SH, Schneider BL, Reitzer L. (2010) Genetics and regulation of the major enzymes of alanine synthesis in Escherichia coli J Bacteriol 192 5304-11.

 Marienhagen J, Kennerknecht N, Sahm H, Eggeling L. (2005) Functional analysis of all aminotransferase proteins inferred from the genome sequence of Corynebacterium glutamicum J Bacteriol 187 7639-46.

 Ward, D.E.; Kengen, S.W.; van Der Oost, J.; de Vos, W.M. (2000) Purification and characterization of the alanine aminotransferase from the hyperthermophilic Archaeon pyrococcus furiosus and its role in alanine production J Bacteriol 182 2559-2566.

Articles on 2.6.1.2.a
last changed 2017/11/15 10:31

B6db families