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B6db families: 2.6.1.39.a

2.6.1.39 a
Activity 2.6.1.39
Description 2-aminoadipate aminotransferase. (family a)
Notes The yeast gene listed here encodes a transaminase with broad substrate specificity; even though it apparently prefers 2-aminoadipate as a substrate, it is annotated as aromatic aminoacid aminotransferase.
The human enzyme listed here may be able to transaminate kynurenine and is sometimes annotated as kynurenine aminotransferase II.
PDB 2R2N;2VGZ;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
10
Sequences in seed alignment
FungiEAA58722.1 (Aspergillus nidulans FGSC A4); YGL202W (Saccharomyces cerevisiae ); NP_593270.1 (Schizosaccharomyces pombe); EAA28795.1 (Neurospora crassa); EAA46698.1 (Magnaporthe grisea );
MetazoaNP_035964 (Mus musculus); AAM09683 (Homo sapiens); AAH59968 (Xenopus laevis); CAA90507 (Rattus norvegicus);
Other_EukaryaAAO51520 (Dictyostelium discoideum);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence AAM09683
Domain interval 43-417
Catalytic site 263 K
 
References
 Karsten WE, Reyes ZL, Bobyk KD, Cook PF, Chooback L. Source (2011) Mechanism of the aromatic aminotransferase encoded by the Aro8 gene from Saccharomyces cerevisiae Arch Biochem Biophys 516 67-74.

 Goh, D. L.; Patel, A.; Thomas, G. H.; Salomons, G. S.; Schor, D. S.; Jakobs, C.; Geraghty, M. T. (2002) Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT) Mol Genet Metab 76 172-80.

 Urrestarazu, A.; Vissers, S.; Iraqui, I.; Grenson, M. (1998) Phenylalanine- and tyrosine-auxotrophic mutants of Saccharomyces cerevisiae impaired in transamination Mol Gen Genet 257 230-7.

Articles on 2.6.1.39.a
last changed 2009/06/30 14:04

B6db families