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B6db families: 2.6.1.42

2.6.1.42
Activity 2.6.1.42
Description Branched-chain amino acid aminotransferase.
Notes A family of fold-type 4 enzymes, apparently conserved in all kingdoms of life (homologous enzymes from Archaea exist, but they have been omitted from this family as none of them has been functionally characterized).
PDB 1I1K;1EKF;1EKV;
PLP Fold Type IV
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type IV

Number of sequences
38
Sequences in seed alignment
BacteriaAAO91868 (Bacillus anthracis); NP_216726 (Mycobacterium tuberculosis H37Rv); CAC12788 (Staphylococcus carnosus); ZP_00061646 (Clostridium thermocellum ); YBGE_BACSU (Bacillus subtilis); NP_607111 (Streptococcus pyogenes ); ILVE_BACSU (Bacillus subtilis); BAC96006 (Vibrio vulnificus); NP_715980 (Shewanella oneidensis); ZP_00071333 (Trichodesmium erythraeum ); AAK79447 (Clostridium acetobutylicum); ZP_00117422 (Cytophaga hutchinsonii); ILVE_HELPY (Helicobacter pylori); AAQ00003 (Prochlorococcus marinus); AAF34406 (Lactococcus lactis ); ILVE_ECOLI (Escherichia coli); AAM72830 (Chlorobium tepidum); ILVE_SALTY (Salmonella typhimurium); AAO91867 (Bacillus cereus);
FungiBCA1_YEAST (Saccharomyces cerevisiae); BCA1_SCHPO (Schizosaccharomyces pombe); BCA2_YEAST (Saccharomyces cerevisiae);
MetazoaAAH59513 (Danio rerio); BCAT_HUMAN (Homo sapiens); BCAT_CAEEL (Caenorhabditis elegans); AAH48072 (Mus musculus); BCAM_RAT (Rattus norvegicus); BCAT_RAT (Rattus norvegicus); AF184916 (Ovis aries); BCAM_HUMAN (Homo sapiens);
ViridiplantaeAAF07191 (Solanum tuberosum); AAO06962 (Oryza sativa); BCA5_ARATH (Arabidopsis thaliana); BCA3_ARATH (Arabidopsis thaliana); AAF07192 (Solanum tuberosum); BCA2_ARATH (Arabidopsis thaliana); BCA6_ARATH (Arabidopsis thaliana); BCA1_ARATH (Arabidopsis thaliana);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence ILVE_ECOLI
Domain interval 12-290
Catalytic site 160 K
 
References
 Schuster J, Binder S. (2005) The mitochondrial branched-chain aminotransferase (AtBCAT-1) is capable to initiate degradation of leucine, isoleucine and valine in almost all tissues in Arabidopsis thaliana Plant Mol Biol 57 241-54.

 Venos ES, Knodel MH, Radford CL, Berger BJ. (2004) Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis BMC Microbiol 4 39.

 Berger, B.J.; English, S.; Chan, G.; Knodel, M.H. (2003) Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis J Bacteriol 185 2418-31.

 Madsen, S.M.; Beck, H.C.; Ravn, P.; Vrang, A.; Hansen, A.M.; Israelsen, H. (2002) Cloning and inactivation of a branched-chain-amino-acid aminotransferase gene from Staphylococcus carnosus and characterization of the enzyme Appl Environ Microbiol 68 4007-14.

 Yvon, M.; Chambellon, E.; Bolotin, A.; Roudot-Algaron, F. (2000) Characterization and role of the branched-chain aminotransferase (BcaT) isolated from Lactococcus lactis subsp. cremoris NCDO 763 Appl Environ Microbiol 66 571-7.

 Eden, A.; Benvenisty, N. (1998) Characterization of a branched-chain amino-acid aminotransferase from Schizosaccharomyces pombe Yeast 14 189-94.

 Bledsoe, R.K.; Dawson, P.A.; Hutson, S.M. (1997) Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm) Biochim Biophys Acta 1339 9-13.

 Feild MJ, Nguyen DC, Armstrong FB. (1989 ) Amino acid sequence of Salmonella typhimurium branched-chain amino acid aminotransferase Biochemistry 28 5306-10.

 Inoue, K.; Kuramitsu, S.; Aki, K.; Watanabe, Y.; Takagi, T.; Nishigai, M.; Ikai, A.; Kagamiyama, H. (1988) Branched-chain amino acid aminotransferase of Escherichia coli: overproduction and properties J Biochem (Tokyo) 104 777-84.

Articles on 2.6.1.42
last changed 2007/11/19 19:06

B6db families