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B6db families: 2.6.1.51

2.6.1.51
Activity 2.6.1.51
Description Serine--pyruvate aminotransferase.
Notes The sequences included here are close homologs of the enzyme from rat liver organelles, which is identical to isoenzyme 1 of alanine-glyoxylate aminotransferase (2.6.1.44) and also to asparagine-oxo-acid aminotransferase (2.6.1.14) [Noguchi & Fujiwara (1988) JBC 263, 182].
The enzymes from Drosophila and Aedes also show alanine-glyoxylate aminotransferase activity.

We have included in this family a number of bacterial sequences, as they seem very closely related to the metazoan ones. It must be remarked, however, that for none of these bacterial enzymes activity has been tested biochemically. Even for the Nostoc (Anabaena) enzyme, whose structure has been published, functional validation is lacking.

PDB 1H0C;2YOB;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
24
Sequences in seed alignment
ArchaeaNP_343929 (Sulfolobus solfataricus P2);
BacteriaZP_00055197 (Magnetospirillum magnetotacticum); NP_719867 (Shewanella oneidensis MR-1); NP_840135 (Nitrosomonas europaea); AAK65472 (Sinorhizobium meliloti); NP_893037 (Prochlorococcus marinus ); AAF10920 (Deinococcus radiodurans); NP_760338 (Vibrio vulnificus CMCP6); ZP_00115395 (Synechococcus sp. WH 8102); BAB72961.1 (Nostoc sp. PCC 7120);
FungiNP_116623 (Saccharomyces cerevisiae);
MetazoaSPYA_MOUSE (Mus musculus); SPYA_RABIT (Oryctolagus cuniculus); NP_511062 (Drosophila melanogaster); SPYA_FELCA (Felis silvestris catus); CAC17015 (Xenopus laevis); SPYA_HUMAN (Homo sapiens); SPYA_RAT (Rattus norvegicus); T24910 (Caenorhabditis elegans); AAL29468 (Aedes aegypti); SPYA_CALJA (Callithrix jacchus); EAA05410 (Anopheles gambiae str. PEST); CAA71715.1 (Cavia porcellus); AAK26375 (Heterodera glycines);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence SPYA_RAT
Domain interval 45-398
Catalytic site 231 K
 
References Articles on 2.6.1.51
last changed 2014/03/18 13:35

B6db families