B6db families : 2_6_1

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2.6.1.52

Activity

2.6.1.52

Description

Phosphoserine aminotransferase.

Notes

The phosphoserine aminotransferase activity (and the associated enzymes) are diffused in a great variety of organisms. The enzyme sequences are sufficiently similar to each other to be included in a single family, but the gene genealogies are rather confuse.

This family includes only two archaeal sequences, which are very similar to eubacterial (gram +) enzymes, possibly due to a recent horizontal gene transfer. In methanococcales a broad-specificity aminotransferase seems able to carry out the transamination of phosphoserine, as well as those of aspartate, glutamate, alanine, and cysteate (Helgadóttir et al., 2007, J Bacteriol 189(2):575-82). The sequences of these archaeal enzymes are most similar to those of alanine-glyoxylate aminotransferases (EC 2.6.1.51) and may be grouped in an independent family as soon as their substrate specificity becomes better defined.

PDB

1BT4;1BJO;1BJN;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Archaea	SERC_METBA (Methanosarcina barkeri); NP_634935.1 (Methanosarcina mazei Goe1);
Bacteria	NP_104887 (Mesorhizobium loti); CAC08322 (Streptomyces coelicolor); SERC_CHRVO (Chromobacterium violaceum); SERC_PSEST (Pseudomonas stutzeri); SERC_PASMU (Pasteurella multocida); SERC_NEIMA (Neisseria meningitidis); AAO76260 (Bacteroides thetaiotaomicron); SERC_YEREN (Yersinia enterocolitica); SERC_HAEIN (Haemophilus influenzae); ZP_00151949 (Dechloromonas aromatica RCB); CAD74688 (Pirellula sp.); SERC_VIBVU (Vibrio vulnificus); SERC_LACLA (Lactococcus lactis (subsp. lactis)); SERC_BACCR (Bacillus cereus); NP_696810 (Bifidobacterium longum); AAQ66358.1 (Porphyromonas gingivalis); ZP_00093940.1 (Novosphingobium aromaticivorans); SERC_MYCTU (Mycobacterium tuberculosis); SERC_BACSU (Bacillus subtilis); SERC_XENNE (Xenorhabdus nematophila); CAD84244 (Nitrosomonas europaea ); SERC_ECOLI (Escherichia coli); SERC_BACCI (Bacillus circulans); CAE29750.1 (Rhodopseudomonas palustris ); SERC_SALTY (Salmonella typhimurium);
Fungi	CAD70964 (Neurospora crassa); EAA50300 (Magnaporthe grisea ); SERC_SCHPO (Schizosaccharomyces pombe); SERC_YEAST (Saccharomyces cerevisiae);
Metazoa	SERC_HUMAN (Homo sapiens); SERC_CAEEL (Caenorhabditis elegans); AAH44467 (Danio rerio); SERC_RABIT (Oryctolagus cuniculus); SERC_DROME (Drosophila melanogaster);
Other_Eukarya	BAD52335 (Entamoeba histolytica);
Viridiplantae	SERC_ARATH (Arabidopsis thaliana); AAM51827 (Oryza sativa ); SERC_SPIOL (Spinacia oleracea);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

SERC_ECOLI

Domain interval

3-349

Catalytic site

198 K

References

Ali V, Nozaki T. (2006) Biochemical and functional characterization of phosphoserine aminotransferase from Entamoeba histolytica, which possesses both phosphorylated and non-phosphorylated serine metabolic pathways Mol Biochem Parasitol 145 :71-83.

Baek, J.Y.; Jun do, Y.; Taub, D.; Kim, Y.H. (2003) Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of L-serine biosynthesis Biochem J 373 191-200.

Saito, K.; Takagi, Y.; Ling, H.C.; Takahashi, H.; Noji, M. (1997) Molecular cloning, characterization and expression of cDNA encoding phosphoserine aminotransferase involved in phosphorylated pathway of serine biosynthesis from spinach Plant Mol Biol 33 359-66.

Battchikova, N.; Himanen, J. P.; Ahjolahti, M.; Korpela, T. (1996) Phosphoserine aminotransferase from Bacillus circulans subsp. alkalophilus: purification, gene cloning and sequencing Biochim Biophys Acta 1295 187-94..

Metcalf, W.W.; Zhang, J.K.; Shi, X.; Wolfe, R.S. (1996) Molecular, genetic, and biochemical characterization of the serC gene of Methanosarcina barkeri Fusaro J Bacteriol 178 5797-802.

Articles on 2.6.1.52

last changed

2007/12/05 18:59