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B6db families: 2.6.1.52

2.6.1.52
Activity 2.6.1.52
Description Phosphoserine aminotransferase.
Notes The phosphoserine aminotransferase activity (and the associated enzymes) are diffused in a great variety of organisms. The enzyme sequences are sufficiently similar to each other to be included in a single family, but the gene genealogies are rather confuse.

This family includes only two archaeal sequences, which are very similar to eubacterial (gram +) enzymes, possibly due to a recent horizontal gene transfer. In methanococcales a broad-specificity aminotransferase seems able to carry out the transamination of phosphoserine, as well as those of aspartate, glutamate, alanine, and cysteate (Helgadóttir et al., 2007, J Bacteriol 189(2):575-82). The sequences of these archaeal enzymes are most similar to those of alanine-glyoxylate aminotransferases (EC 2.6.1.51) and may be grouped in an independent family as soon as their substrate specificity becomes better defined.

PDB 1BT4;1BJO;1BJN;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
40
Sequences in seed alignment
ArchaeaSERC_METBA (Methanosarcina barkeri); NP_634935.1 (Methanosarcina mazei Goe1);
BacteriaSERC_PSEST (Pseudomonas stutzeri); SERC_YEREN (Yersinia enterocolitica); SERC_PASMU (Pasteurella multocida); CAC08322 (Streptomyces coelicolor); SERC_BACCI (Bacillus circulans); NP_104887 (Mesorhizobium loti); SERC_XENNE (Xenorhabdus nematophila); AAQ66358.1 (Porphyromonas gingivalis); SERC_BACCR (Bacillus cereus); SERC_SALTY (Salmonella typhimurium); CAE29750.1 (Rhodopseudomonas palustris ); SERC_MYCTU (Mycobacterium tuberculosis); ZP_00093940.1 (Novosphingobium aromaticivorans); AAO76260 (Bacteroides thetaiotaomicron); SERC_CHRVO (Chromobacterium violaceum); ZP_00151949 (Dechloromonas aromatica RCB); SERC_NEIMA (Neisseria meningitidis); CAD84244 (Nitrosomonas europaea ); SERC_VIBVU (Vibrio vulnificus); SERC_HAEIN (Haemophilus influenzae); SERC_ECOLI (Escherichia coli); SERC_LACLA (Lactococcus lactis (subsp. lactis)); CAD74688 (Pirellula sp.); NP_696810 (Bifidobacterium longum); SERC_BACSU (Bacillus subtilis);
FungiSERC_SCHPO (Schizosaccharomyces pombe); SERC_YEAST (Saccharomyces cerevisiae); CAD70964 (Neurospora crassa); EAA50300 (Magnaporthe grisea );
MetazoaAAH44467 (Danio rerio); SERC_HUMAN (Homo sapiens); SERC_CAEEL (Caenorhabditis elegans); SERC_DROME (Drosophila melanogaster); SERC_RABIT (Oryctolagus cuniculus);
Other_EukaryaBAD52335 (Entamoeba histolytica);
ViridiplantaeAAM51827 (Oryza sativa ); SERC_SPIOL (Spinacia oleracea); SERC_ARATH (Arabidopsis thaliana);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence SERC_ECOLI
Domain interval 3-349
Catalytic site 198 K
 
References Articles on 2.6.1.52
last changed 2007/12/05 18:59

B6db families