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B6db families: 2.6.1.7

2.6.1.7
Activity 2.6.1.7
Description Kynurenine--oxoglutarate aminotransferase
Notes The family is composed by enzymes similar to the prototypical rat kynurenine aminotransferase, but endowed with a broad substrate specificity. For example, the rat kynurenine aminotransferase I also shows alpha-aminoadipate aminotransferase activity (2.6.1.39) while the T. thermophilus enzyme has been found responsible for the kynurenine-oxoglutarate aminotransferase reaction and for the glutamine-phenylpyruvate reaction (2.6.1.64).
The family includes the mammalian proteins earlier termed 'glutamine transaminase K'.
PDB 1YIZ;3B46;1V2F;4WLH;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
24
Sequences in seed alignment
BacteriaAAK22723 (Caulobacter crescentus CB15); ZP_00018479 (Chloroflexus aurantiacus); NP_947358 (Rhodopseudomonas palustris); ZP_00015517 (Rhodospirillum rubrum); T36548 (Streptomyces coelicolor); ZP_00056895 (Thermobifida fusca); BAD06364 (Thermus thermophilus);
FungiEAA51669 (Magnaporthe grisea); XP_322605 (Neurospora crassa); T39011 (Schizosaccharomyces pombe); NP_012475 (Saccharomyces cerevisiae);
MetazoaBAC31248 (Mus musculus); CAE65291 (Caenorhabditis briggsae); XP_309491 (Anopheles gambiae); S52790 (Homo sapiens); NP_510553 (Caenorhabditis elegans); AAB32197 (Rattus norvegicus); XP_131229 (Mus musculus); AAH51239 (Xenopus laevis); BAG12983 (Haemaphysalis longicornis); CAB44334 (Takifugu rubripes); AF395204 (Aedes aegypti); NP_650121 (Drosophila melanogaster); AAH53152 (Danio rerio);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence AAB32197
Domain interval 28-415
Catalytic site 247 K
 
References
 Nadvi NA, Salam NK, Park J, Akladios FN, Kapoor V, Collyer CA, Gorrell MD, Church WB (2017) High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate Protein Sci 26 727-736.

 Battsetseg B, Boldbaatar D, Battur B, Xuan X, Fujisaki K. (2009) Cloning and molecular characterization of tick kynurenine aminotransferase (HlKAT) from Haemaphysalis longicornis (Acari: Ixodidae). Parasitol Res. 105 669-79.

 Han Q, Robinson H, Cai T, Tagle DA, Li J. (2009) Biochemical and structural properties of mouse kynurenine aminotransferase III Mol Cell Biol 29 784-93.

 Wogulis M, Chew ER, Donohoue PD, Wilson DK. (2008) Identification of Formyl Kynurenine Formamidase and Kynurenine Aminotransferase from Saccharomyces cerevisiae Using Crystallographic, Bioinformatic and Biochemical Evidence Biochemistry 47 1608-21.

 Han, Q.; Li, J.; Li, J. (2004) pH dependence, substrate specificity and inhibition of human kynurenine aminotransferase I Eur J Biochem 271 4804-14.

 Hosono, A.; Mizuguchi, H.; Hayashi, H.; Goto, M.; Miyahara, I.; Hirotsu, K.; Kagamiyama, H. (2003) Glutamine:phenylpyruvate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus HB8 J Biochem (Tokyo) 134 843-51.

 Fang, J.; Han, Q.; Li, J. (2002) Isolation, characterization, and functional expression of kynurenine aminotransferase cDNA from the yellow fever mosquito, Aedes aegypti Insect Biochem Mol Biol 32 943-50.

 Mosca, M.; Cozzi, L.; Breton, J.; Avanzi, N.; Toma, S.; Okuno, E.; Schwarcz, R.; Speciale, C.; Magagnin, S.; Mostardini, M.; Benatti, L. (1996) Cloning of rat and human kynurenine aminotransferase Adv Exp Med Biol 398 449-54.

 Buchli, R.; Alberati-Giani, D.; Malherbe, P.; Kohler, C.; Broger, C.; Cesura, A. M. (1995) Cloning and functional expression of a soluble form of kynurenine/alpha- aminoadipate aminotransferase from rat kidney J Biol Chem 270 29330-5.

Articles on 2.6.1.7
last changed 2017/09/15 10:50

B6db families