B6db families : 2_6_1

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2.6.1.76

Activity

2.6.1.76

Description

Diaminobutyrate-2-oxoglutarate transaminase.

Notes

This rather compact family (related to 2.6.1.19_b, GABA aminotransferase) includes bacterial enzymes catalyzing the first step in the ectoine biosynthesis pathway. The enzymes from Halomonas require potassium for function.

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

NP_691439 (Oceanobacillus iheyensis); NP_106518 (Mesorhizobium loti); H82412 (Vibrio cholerae ); ZP_00123759 (Pseudomonas syringae pv. syringae B728a); AAQ60472 (Chromobacterium violaceum); ECB1_HALEL (Halomonas elongata); NP_884153 (Bordetella parapertussis ); NP_873252 (Haemophilus ducreyi); ZP_00122874 (Haemophilus somnus ); C83345 (Pseudomonas aeruginosa); AEJ36141 (Prauserella alba); NP_444034.1 (Rhizobium sp. NGR234); AAK01505 (Pseudomonas aeruginosa); DAT_HAEIN (Haemophilus influenzae); AAK95337 (Moraxella catarrhalis); NP_657172 (Bacillus anthracis); AAK00182 (Bradyrhizobium sp.); ECB2_HALEL (Halomonas elongata); BAB04638 (Bacillus halodurans); AAS02095 (Streptomyces chrysomallus); AAY96771 (Methylobacter alcaliphilus); ECTB_MARHA (Marinococcus halophilus); NP_798100 (Vibrio parahaemolyticus); CAE09965 (Wolinella succinogenes); DAT_ACIBA (Acinetobacter baumannii); CAD75280 (Pirellula sp.); AF316874_2 (Sporosarcina pasteurii); CAE16635 (Photorhabdus luminescens ); RHBA_RHIME (Rhizobium meliloti); ZP_00067758 (Microbulbifer degradans);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

DAT_ACIBA

Domain interval

30-369

Catalytic site

289 K

References

Vandenende C.S.; Vlasschaert, M.; Seah, S.Y. (2004) Functional characterization of an aminotransferase required for pyoverdine siderophore biosynthesis in Pseudomonas aeruginosa PAO1 J Bacteriol 186 5596-602.

Ono, H.; Sawada, K.; Khunajakr, N.; Tao, T.; Yamamoto, M.; Hiramoto, M.; Shinmyo, A.; Takano, M.; Murooka, Y. (1999) Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata J Bacteriol 181 91-9.

Ikai, H.; Yamamoto, S. (1998) Two genes involved in the 1,3-diaminopropane production pathway in Haemophilus influenzae Biol Pharm Bull 21 170-3.

Ikai, H.; Yamamoto, S. (1997) Identification and analysis of a gene encoding L-2,4-diaminobutyrate:2- ketoglutarate 4-aminotransferase involved in the 1,3-diaminopropane production pathway in Acinetobacter baumannii J Bacteriol 179 5118-25.

Articles on 2.6.1.76

last changed

2014/07/10 20:19