B6db families : 2_6_1

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2.6.1.76

Activity

2.6.1.76

Description

Diaminobutyrate-2-oxoglutarate transaminase

Notes

This rather compact family (related to 2.6.1.19_b, GABA aminotransferase) includes bacterial enzymes catalyzing the first step in the ectoine biosynthesis pathway. The enzymes from Halomonas require potassium for function.

PDB

6RL5;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

DAT_ACIBA (Acinetobacter baumannii); AAY96771 (Methylobacter alcaliphilus); AAS02095 (Streptomyces chrysomallus); ECB2_HALEL (Halomonas elongata); CAD75280 (Pirellula sp.); ECTB_MARHA (Marinococcus halophilus); ZP_00067758 (Microbulbifer degradans); AAG05801 (Pseudomonas aeruginosa PAO1); AAK00182 (Bradyrhizobium sp.); DAT_HAEIN (Haemophilus influenzae); ZP_00123759 (Pseudomonas syringae pv. syringae B728a); NP_106518 (Mesorhizobium loti); WP_015737573 (Paenibacillus lautus Y412MC10); AAQ60472 (Chromobacterium violaceum); RHBA_RHIME (Rhizobium meliloti); AAK01505 (Pseudomonas aeruginosa); AF316874_2 (Sporosarcina pasteurii); BAB04638 (Bacillus halodurans); ECB1_HALEL (Halomonas elongata); NP_657172 (Bacillus anthracis); ZP_00122874 (Haemophilus somnus ); AEJ36141 (Prauserella alba); NP_691439 (Oceanobacillus iheyensis); AWB74157 (Vibrio cholerae ); CAE16635 (Photorhabdus luminescens ); NP_444034 (Rhizobium sp. NGR234); AAK95337 (Moraxella catarrhalis); AZA08149 (Bacillus clausii NIOT-DSB04); NP_884153 (Bordetella parapertussis ); CAE09965 (Wolinella succinogenes);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

DAT_ACIBA

Domain interval

30-369

Catalytic site

289 K

References

Anburajan L, Meena B, Vinithkumar NV, Kirubagaran R, Dharani G (2019) Functional characterization of a major compatible solute in Deep Sea halophilic eubacteria of active volcanic Barren Island, Andaman and Nicobar Islands, India Infect Genet Evol 73 261-265.

Richter AA, Mais C-N, Czech L, Geyer K, Hoeppner A, Smits Sander HJ, Erb TJ, Bange G, Bremer E (2019) Biosynthesis of the Stress-Protectant and Chemical Chaperon Ectoine: Biochemistry of the Transaminase EctB Front Microbiol 10 2811.

Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ. (2009) An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae J Biol Chem 284 9899-907.

Vandenende C.S.; Vlasschaert, M.; Seah, S.Y. (2004) Functional characterization of an aminotransferase required for pyoverdine siderophore biosynthesis in Pseudomonas aeruginosa PAO1 J Bacteriol 186 5596-602.

Ono, H.; Sawada, K.; Khunajakr, N.; Tao, T.; Yamamoto, M.; Hiramoto, M.; Shinmyo, A.; Takano, M.; Murooka, Y. (1999) Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata J Bacteriol 181 91-9.

Ikai, H.; Yamamoto, S. (1998) Two genes involved in the 1,3-diaminopropane production pathway in Haemophilus influenzae Biol Pharm Bull 21 170-3.

Ikai, H.; Yamamoto, S. (1997) Identification and analysis of a gene encoding L-2,4-diaminobutyrate:2- ketoglutarate 4-aminotransferase involved in the 1,3-diaminopropane production pathway in Acinetobacter baumannii J Bacteriol 179 5118-25.

Articles on 2.6.1.76

last changed

2020/03/01 11:18