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B6db families: 2.6.1.83.a

2.6.1.83 a
Activity 2.6.1.83
Description LL-diaminopimelate aminotransferase (family a)
PDB 2Z1Z;2Z20;3QGU;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
14
Sequences in seed alignment
ArchaeaYP_447955 (Methanosphaera stadtmanae); NP_275195 (Methanothermobacter thermautotrophicus);
BacteriaYP_001039489 (Clostridium thermocellum); DAPAT_CHLTR (Chlamydia trachomatis); DAPAT_PARUW (Candidatus Protochlamydia amoebophila); YP_001551507 (Prochlorococcus marinus); WP_009961032 (Verrucomicrobium spinosum DSM 4136); ZP_01853115 (Planctomyces maris DSM 8797);
ViridiplantaeABE84803 (Medicago truncatula); XP_001693061 (Chlamydomonas reinhardtii); NP_567934 (Arabidopsis thaliana); XP_001416567 (Ostreococcus lucimarinus); ABK93412 (Populus trichocarpa); BT013469 (Lycopersicon esculentum);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence NP_567934
Domain interval 91-456
Catalytic site 305 K
 
References
 Nachar VR, Savka FC, McGroty SE, Donovan KA, North RA, Dobson RC, Buckley LJ, Hudson AO (2012) Genomic and Biochemical Analysis of the Diaminopimelate and Lysine Biosynthesis Pathway in Verrucomicrobium spinosum: Identification and Partial Characterization of L,L-Diaminopimelate Aminotransferase and UDP-N-Acetylmuramoylalanyl-D-glutamyl-2,6-meso-Diaminopimelate Ligase Front Microbiol 3 183.

 Dobson RC, Girón I, Hudson AO (2011) L,L-diaminopimelate aminotransferase from Chlamydomonas reinhardtii: a target for algaecide development PLoS One 6 e20439.

 Graham DE, Huse HK. (2008) Methanogens with pseudomurein use diaminopimelate aminotransferase in lysine biosynthesis FEBS Lett 3582 1369-74.

 Hudson AO, Gilvarg C, Leustek T. (2008) Biochemical and phylogenetic characterization of a novel diaminopimelate biosynthesis pathway in prokaryotes identifies a diverged form of LL-diaminopimelate aminotransferase J Bacteriol 190 3256-63.

 Watanabe N, Cherney MM, van Belkum MJ, Marcus SL, Flegel MD, Clay MD, Deyholos MK, Vederas JC, James MN. (2007) Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia J Mol Biol 371 685-702.

 Hudson AO, Singh BK, Leustek T, Gilvarg C. (2006) An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants Plant Physiol 140 292-301.

 McCoy AJ, Adams NE, Hudson AO, Gilvarg C, Leustek T, Maurelli AT. (2006) L,L-diaminopimelate aminotransferase, a trans-kingdom enzyme shared by Chlamydia and plants for synthesis of diaminopimelate/lysine Proc Natl Acad Sci U S A 103 17909-14.

Articles on 2.6.1.83.a
last changed 2019/05/21 09:02

B6db families