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B6db families: 2.9.1.1

2.9.1.1
Activity 2.9.1.1
Description L-seryl-tRNA(Sec) selenium transferase
Notes A family very distinct from all others, and composed solely of bacterial sequences. Some sequences lacking the tRNA(Sec) binding domain are predicted to have a different function. Absence of tRNA(Sec) binding has been demonstrated for a homologous archaeal protein (see Kaiser J.T. et al., Biochemistry, 2005).
PDB 3W1J;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence SELA_ECOLI
Domain interval 83-452
Catalytic site 295 K
 
References
  Itoh Y1, Bröcker MJ, Sekine S, Hammond G, Suetsugu S, Söll D, Yokoyama S. (2013) Decameric SelA•tRNA(Sec) ring structure reveals mechanism of bacterial selenocysteine formation. Science. 340 75-8.

 Gursinsky, T.; Jager, J.; Andreesen, J. R.; Sohling, B. (2000) A selDABC cluster for selenocysteine incorporation in Eubacterium acidaminophilum Arch Microbiol 174 200-12.

 Tormay, P.; Wilting, R.; Lottspeich, F.; Mehta, P. K.; Christen, P.; Bock, A. (1998) Bacterial selenocysteine synthase--structural and functional properties Eur J Biochem 254 655-61.

 Forchhammer, K.; Leinfelder, W.; Boesmiller, K.; Veprek, B.; Bock, A. (1991) Selenocysteine synthase from Escherichia coli. Nucleotide sequence of the gene (selA) and purification of the protein J Biol Chem 266 6318-23.

Articles on 2.9.1.1
last changed 2017/07/11 17:09

B6db families