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B6db families: 2.9.1.1

2.9.1.1
Activity 2.9.1.1
Description L-seryl-tRNA(Sec) selenium transferase.
Notes A family very distinct from all others, and composed solely of bacterial sequences. Some sequences lacking the tRNA(Sec) binding domain are predicted to have a different function. Absence of tRNA(Sec) binding have been demonstrated for a homologous archaeal protein (see Kaiser J.T. et al., Biochemistry, 2005).
PDB 3w1j;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
28
Sequences in seed alignment
BacteriaSELA_HAEIN (Haemophilus influenzae); SELA_RHIME (Rhizobium meliloti); SELA_YERPE (Yersinia pestis); SELA_DESBA (Desulfovibrio baculatus); NP_932048 (Photorhabdus luminescens); ZP_00129049 (Desulfovibrio desulfuricans); SELA_MOOTH (Moorella thermoacetica); ZP_00017571 (Chloroflexus aurantiacus); ZP_00034655 (Burkholderia fungorum); SELA_ECOLI (Escherichia coli); SELA_CAMJE (Campylobacter jejuni); SELA_THETN (Thermoanaerobacter tengcongensis); NP_874321 (Haemophilus ducreyi); SELA_EUBAC (Eubacterium acidaminophilum); AAS12994 (Treponema denticola ); ZP_00098334 (Desulfitobacterium hafniense); ZP_00081487 (Geobacter metallireducens); CAE09951 (Wolinella succinogenes); SELA_PASMU (Pasteurella multocida); SELA_PSEPK (Pseudomonas putida ); NP_860271 (Helicobacter hepaticus); SELA_SALTY (Salmonella typhimurium); NP_715747 (Shewanella oneidensis); SELA_CLOPE (Clostridium perfringens ); SELA_PSEAE (Pseudomonas aeruginosa); AAR36759 (Geobacter sulfurreducens); ZP_00088085 (Pseudomonas fluorescens); SELA_AQUAE (Aquifex aeolicus);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence SELA_ECOLI
Domain interval 83-452
Catalytic site 295 K
 
References
  Itoh Y1, Bröcker MJ, Sekine S, Hammond G, Suetsugu S, Söll D, Yokoyama S. (2013) Decameric SelA•tRNA(Sec) ring structure reveals mechanism of bacterial selenocysteine formation. Science. 340 75-8.

 Gursinsky, T.; Jager, J.; Andreesen, J. R.; Sohling, B. (2000) A selDABC cluster for selenocysteine incorporation in Eubacterium acidaminophilum Arch Microbiol 174 200-12.

 Tormay, P.; Wilting, R.; Lottspeich, F.; Mehta, P. K.; Christen, P.; Bock, A. (1998) Bacterial selenocysteine synthase--structural and functional properties Eur J Biochem 254 655-61.

 Forchhammer, K.; Leinfelder, W.; Boesmiller, K.; Veprek, B.; Bock, A. (1991) Selenocysteine synthase from Escherichia coli. Nucleotide sequence of the gene (selA) and purification of the protein J Biol Chem 266 6318-23.

Articles on 2.9.1.1
last changed 2014/07/01 10:26

B6db families