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|
3.7.1.3 |
Activity |
3.7.1.3 |
Description |
Kynureninase |
Notes |
The family encompasses bacterial, fungal and animal genes (the activity has not been described in other organisms). Note that many fungi contain two kinureninase genes - presumably, one encodes an inducible enzyme, whereas expression of the other is constitutive. |
PDB |
1QZ9;2HZP; |
PLP Fold Type |
I |
PLP-dependent Domain |
|
Number of sequences |
27 |
Sequences in seed alignment |
|
Reference sequence |
KYNU_RAT |
Domain interval |
69-450 |
Catalytic site |
276 K |
| |
References |
Zummo FP, Marineo S, Pace A, Civiletti F, Giardina A, Puglia AM (2012) Tryptophan catabolism via kynurenine production in Streptomyces coelicolor: identification of three genes coding for the enzymes of tryptophan to anthranilate pathway Appl Microbiol Biotechnol 94 719-28. Walsh, H. A.; Botting, N. P. (2002) Purification and biochemical characterization of some of the properties of recombinant human kynureninase Eur J Biochem 269 2069-74. Koushik, S. V.; Sundararaju, B.; McGraw, R. A.; Phillips, R. S. (1997) Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens Arch Biochem Biophys 344 301-8. Toma, S.; Nakamura, M.; Tone, S.; Okuno, E.; Kido, R.; Breton, J.; Avanzi, N.; Cozzi, L.; Speciale, C.; Mostardini, M.; Gatti, S.; Benatti, L. (1997) Cloning and recombinant expression of rat and human kynureninase FEBS Lett 408 5-10. Articles on 3.7.1.3 |
last changed |
2007/12/20 20:55 |
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