Activities | Families | Sequences | Fold types | References | Help
B6db families: 3.7.1.3

3.7.1.3
Activity 3.7.1.3
Description Kynureninase.
Notes The family encompasses bacterial, fungal and animal genes (the activity has not been described in other organisms).
Note that many fungi contain two kinureninase genes - presumably, one encodes an inducible enzyme, whereas expression of the other is constitutive.
PDB 1QZ9;2HZP;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
23
Sequences in seed alignment
BacteriaBAC12712 (Oceanobacillus iheyensis); ZP_00118864.1 (Cytophaga hutchinsonii); NP_279867 (Halobacterium sp. NRC-1); NP_641933.1 (Xanthomonas axonopodis pv. citri str. 306); NP_656639 (Bacillus anthracis A2012); AAQ86995 (Polaribacter filamentus); NP_102390.1 (Mesorhizobium loti); AAP05310 (Chlamydophila caviae ); CAE30744 (Bordetella bronchiseptica); ZP_00029890 (Burkholderia fungorum); NP_636924.1 (Xanthomonas campestris pv. campestris str. ATCC 33913); 1QZ9A (Pseudomonas fluorescens); NP_627839.1 (Streptomyces coelicolor ); NP_518880 (Ralstonia solanacearum);
FungiEAA27546 (Neurospora crassa); EAA72333 (Gibberella zeae); EAA57815 (Aspergillus nidulans); KYNU_YEAST (Saccharomyces cerevisiae);
MetazoaKYNU_CAEEL (Caenorhabditis elegans); KYNU_RAT (Rattus norvegicus); KYNU_HUMAN (Homo sapiens); CAE68870 (Caenorhabditis briggsae); XP_130193.1 (Mus musculus);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence KYNU_RAT
Domain interval 69-450
Catalytic site 276 K
 
References
 Walsh, H. A.; Botting, N. P. (2002) Purification and biochemical characterization of some of the properties of recombinant human kynureninase Eur J Biochem 269 2069-74.

 Koushik, S. V.; Sundararaju, B.; McGraw, R. A.; Phillips, R. S. (1997) Cloning, sequence, and expression of kynureninase from Pseudomonas fluorescens Arch Biochem Biophys 344 301-8.

 Toma, S.; Nakamura, M.; Tone, S.; Okuno, E.; Kido, R.; Breton, J.; Avanzi, N.; Cozzi, L.; Speciale, C.; Mostardini, M.; Gatti, S.; Benatti, L. (1997) Cloning and recombinant expression of rat and human kynureninase FEBS Lett 408 5-10.

Articles on 3.7.1.3
last changed 2007/12/20 20:55

B6db families