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4.1.1.107 |
Activity |
4.1.1.107 |
Description |
3,4-dihydroxyphenylacetaldehyde synthase |
Notes |
Phylogenetically, these enzymes are derived from, and strictly similar to, aromatic amino acid decarboxylases (family 4.1.1.28).
A distinctive residue is N192 (in the reference sequence NP_476592 from D. melanogaster); AAA decarboxylases have a His at this position. |
PLP Fold Type |
I |
PLP-dependent Domain |
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Number of sequences |
12 |
Sequences in seed alignment |
|
Reference sequence |
NP_476592 |
Domain interval |
35-414 |
Catalytic site |
303 K |
| |
References |
Liang J, Han Q, Ding H, Li J (2017) Biochemical identification of residues that discriminate between 3,4-dihydroxyphenylalanine decarboxylase and 3,4-dihydroxyphenylacetaldehyde synthase-mediated reactions Insect Biochem Mol Biol 91 34-43. Vavricka C, Han Q, Huang Y, Erickson SM, Harich K, Christensen BM, Li J. (2011) From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects IPLoS One 6 e16124. Articles on 4.1.1.107 |
last changed |
2018/05/09 15:37 |
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