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B6db families:
Description Aspartate 4-decarboxylase
Notes Very distinct family, composed only of bacterial sequences, distantly related to aspartate and aromatic aminoacid aminotransferases.
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 12
Sequences in seed alignment
BacteriaBAB80047 (Clostridium perfringens str. 13); AAO80840 (Enterococcus faecalis); CAI54608 (Lactobacillus sakei subsp. sakei 23K); ZP_00031314 (Burkholderia fungorum); BAC65229 (Pseudomonas dacunhae ATCC 21192); AAK58507 (Alcaligenes faecalis); BAB92080 (Tetragenococcus halophilus ); AAO75842 (Bacteroides thetaiotaomicron); NP_770117 (Bradyrhizobium japonicum); WP_012492116 (Lactobacillus casei); AAL04506 (Bacteroides fragilis); AAQ07948 (Pseudomonas sp. ATCC 19121);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence AAK58507
Domain interval 111-515
Catalytic site 315 K
 Becerra JE, Rodríguez-Díaz J, Gozalbo-Rovira R, Palomino-Schätzlein M, Zúńiga M, Monedero V, Yebra MJ (2020) Unique Microbial Catabolic Pathway for the Human Core N-Glycan Constituent Fucosyl-α-1,6-N-Acetylglucosamine-Asparagine mBio 11 e02804-19.

 Lima S, Sundararaju B, Huang C, Khristoforov R, Momany C, Phillips RS. (2009) The crystal structure of the Pseudomonas dacunhae aspartate-beta-decarboxylase dodecamer reveals an unknown oligomeric assembly for a pyridoxal-5'-phosphate-dependent enzyme J Mol Biol 388 98-108.

 Wang NC, Lee CY. (2006) Molecular cloning of the aspartate 4-decarboxylase gene from Pseudomonas sp. ATCC 19121 and characterization of the bifunctional recombinant enzyme Appl Microbiol Biotechnol 73 339-48.

 Chaillou S, Champomier-Vergčs MC, Cornet M, Crutz-Le Coq AM, Dudez AM, Martin V, Beaufils S, Darbon-Rongčre E, Bossy R, Loux V, Zagorec M. (2005) The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K. Nat Biotechnol. 23 1527-33.

 Abe, K.; Ohnishi, F.; Yagi, K.; Nakajima, T.; Higuchi, T.; Sano, M.; Machida, M.; Sarker, R.I.; Maloney, P.C. (2002) Plasmid-encoded asp operon confers a proton motive metabolic cycle catalyzed by an aspartate-alanine exchange reaction J Bacteriol 184 2906-13.

 Chen, C-C. Chou, T-L. Lee, C-Y. (2000) Cloning, expression and characterization of L-aspartate beta-decarboxylase gene from Alcaligenes faecalis CCRC 11585 J Industrial Microbiol Biotechnol 25 132-140.

Articles on
last changed 2009/06/30 11:31

B6db families