B6db families : 4_1_1_15

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4.1.1.15 a

Activity

4.1.1.15

Description

Glutamate decarboxylase. (family a)

Notes

This family encompasses exclusively metazoan glutamate decarboxylase sequences.
Two isoforms of glutamate decarboxylase, encoded by different genes, occur in mammalian tissues: a 67-kDa form (DCE1 or GAD67) and a 65-kDa form (DCE2 or GAD65).
Alternate splicing produces smaller variants of GAD67 in the brain of mice and rat embryos. Another splice variant of GAD67 (termed GAD25 and devoid of GAD enzymatic activity) is produced in human islets, testis and adrenal cortex.

PDB

2OKK;2OKJ;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Metazoa

AAF73187 (Carassius auratus); NP_499689.1 (Caenorhabditis elegans); DCE2_PIG (Sus scrofa); DCE2_HUMAN (Homo sapiens); DCE1_RAT (Rattus norvegicus); DCE2_MOUSE (Mus musculus); BAB88854.1 (Ciona intestinalis); AAF73186 (Carassius auratus); NP_919400 (Danio rerio); A30999 (Drosophila melanogaster); DCE1_PIG (Sus scrofa); DCE2_RAT (Rattus norvegicus); CAE69543 (Caenorhabditis briggsae); DCE1_MOUSE (Mus musculus); DCE1_FELCA (Felis silvestris catus); EAA11955.2 (Anopheles gambiae str. PEST); AAA96273 (Xenopus laevis); DCE1_HUMAN (Homo sapiens);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

DCE1_RAT

Domain interval

143-517

Catalytic site

404 K

References

Jin, Y.; Jorgensen, E.; Hartwieg, E.; Horvitz, H.R. (1999) The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development J Neurosci 19 539-48..

Bu, D. F.; Erlander, M. G.; Hitz, B. C.; Tillakaratne, N. J.; Kaufman, D. L.; Wagner-McPherson, C. B.; Evans, G. A.; Tobin, A. J. (1992) Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene Proc Natl Acad Sci U S A 89 2115-9..

Jackson, F.R.; Newby, L.M.; Kulkarni, S.J. (1990) Drosophila GABAergic systems: sequence and expression of glutamic acid decarboxylase J Neurochem 54 1068-78..

Wyborski, R. J.; Bond, R. W.; Gottlieb, D. I. (1990) Characterization of a cDNA coding for rat glutamic acid decarboxylase Brain Res Mol Brain Res 8 193-8..

Articles on 4.1.1.15.a

last changed

2008/01/03 12:33