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B6db families: 4.1.1.15.a

4.1.1.15 a
Activity 4.1.1.15
Description Glutamate decarboxylase. (family a)
Notes This family encompasses exclusively metazoan glutamate decarboxylase sequences.
Two isoforms of glutamate decarboxylase, encoded by different genes, occur in mammalian tissues: a 67-kDa form (DCE1 or GAD67) and a 65-kDa form (DCE2 or GAD65).
Alternate splicing produces smaller variants of GAD67 in the brain of mice and rat embryos. Another splice variant of GAD67 (termed GAD25 and devoid of GAD enzymatic activity) is produced in human islets, testis and adrenal cortex.
PDB 2OKK;2OKJ;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
19
Sequences in seed alignment
MetazoaDCE2_MOUSE (Mus musculus); AAA96273 (Xenopus laevis); AAF73187 (Carassius auratus); BAB88854 (Ciona intestinalis); A30999 (Drosophila melanogaster); NP_919400 (Danio rerio); NP_499689 (Caenorhabditis elegans); CAE69543 (Caenorhabditis briggsae); DCE2_HUMAN (Homo sapiens); DCE1_RAT (Rattus norvegicus); EAA11955 (Anopheles gambiae str. PEST); DCE2_PIG (Sus scrofa); DCE2_RAT (Rattus norvegicus); DCE1_PIG (Sus scrofa); DCE1_MOUSE (Mus musculus); DCE1_FELCA (Felis silvestris catus); DCE1_HUMAN (Homo sapiens); AAF73186 (Carassius auratus); AFX68721 (Mus musculus);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence DCE1_RAT
Domain interval 143-517
Catalytic site 404 K
 
References
 Ilg T, Berger M, Noack S, Rohwer A, Gaßel M. (2013) Glutamate decarboxylase of the parasitic arthropods Ctenocephalides felis and Rhipicephalus microplus: gene identification, cloning, expression, assay development, identification of inhibitors by high throughput screening and comparison with the orthologs from Drosophila melanogaster and mouse. Insect Biochem Mol Biol. 43 162-77.

 Yunlong Zhuang, Guijie Ren, Chunmei He, Xinye Li, Qingmei Meng, Chuanfu Zhu, Rongchun Wang, Juren Zhang (2010) Cloning and Characterization of a Maize cDNA Encoding Glutamate Decarboxylase Plant Molecular Biology Reporter 28 620-626.

 Jin, Y.; Jorgensen, E.; Hartwieg, E.; Horvitz, H.R. (1999) The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development J Neurosci 19 539-48.

 Bu, D. F.; Erlander, M. G.; Hitz, B. C.; Tillakaratne, N. J.; Kaufman, D. L.; Wagner-McPherson, C. B.; Evans, G. A.; Tobin, A. J. (1992) Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene Proc Natl Acad Sci U S A 89 2115-9.

 Jackson, F.R.; Newby, L.M.; Kulkarni, S.J. (1990) Drosophila GABAergic systems: sequence and expression of glutamic acid decarboxylase J Neurochem 54 1068-78.

 Wyborski, R. J.; Bond, R. W.; Gottlieb, D. I. (1990) Characterization of a cDNA coding for rat glutamic acid decarboxylase Brain Res Mol Brain Res 8 193-8.

Articles on 4.1.1.15.a
last changed 2008/01/03 12:33

B6db families