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B6db families: 4.1.1.15.b

4.1.1.15 b
Activity 4.1.1.15
Description Glutamate decarboxylase (family b)
Notes This family includes sequences from bacteria, fungi and plants. Similar sequences also exist in archaea, but they were not included here because none of them has been functionally validated.

Bacterial glutamate decarboxylase (GAD) is a homohexameric enzyme of about 330 kDa, which plays an important role in the maintenance of cellular homeostasis in acid environments.
Plant GAD differs from the bacterial enzyme in having a C-terminal extension of 33 amino acids within which resides a calmodulin (CaM)-binding domain. In plants, the enzyme product, GABA, is generally considered a metabolite, mostly produced in response to stress, but some evidences exist that it may also function as a signal molecule.

PDB 1PMM;5GP4;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences 0
Reference sequence DCEA_ECOLI
Domain interval 33-383
Catalytic site 276 K
 
References Articles on 4.1.1.15.b
last changed 2018/07/26 10:39

B6db families