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B6db families: 4.1.1.18.d

4.1.1.18 d
Activity 4.1.1.18
Description Lysine decarboxylase (family d)
Notes Family built around the functionally validated enzyme from Lycopodium (moss).
These enzymes are Fold-type III sequences, with activity against both L-Lys and (to a lesser extent) L-Orn. They apparently originated from ancestral L-Orn decarboxylases independently of the enzymes in family 4.1.1.18_a.
PLP Fold Type III
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type III

Reference sequence BAR42911
Domain interval 94-435
Catalytic site 123 K
 
References
 Xu B, Lei L, Zhu X, Zhou Y, Xiao Y (2017) Identification and characterization of L-lysine decarboxylase from Huperzia serrata and its role in the metabolic pathway of lycopodium alkaloid Phytochemistry 136 23-30.

 Bunsupa S, Hanada K, Maruyama A, Aoyagi K, Komatsu K, Ueno H, Yamashita M, Sasaki R, Oikawa A, Saito K, Yamazaki M. (2016) Molecular Evolution and Functional Characterization of a Bifunctional Decarboxylase Involved in Lycopodium Alkaloid Biosynthesis Plant Physiol 171 2432-44.

Articles on 4.1.1.18.d
last changed 2018/05/04 10:05

B6db families