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|
4.1.1.22 a |
Activity |
4.1.1.22 |
Description |
Histidine decarboxylase (family a) |
Notes |
This family encompasses a group of closely related enzymes from gram-negative bacteria. The closest validated homologs are plant serine decarboxylases. His decarboxylases from gram-positive bacteria use a pyruvoyl cofactor instead of of PLP. |
PLP Fold Type |
I |
PLP-dependent Domain |
|
Number of sequences |
10 |
Sequences in seed alignment |
|
Reference sequence |
DCHS_MORMO |
Domain interval |
22-331 |
Catalytic site |
233 K |
| |
References |
Sattely ES, Walsh CT (2008) A latent oxazoline electrophile for N-O-C bond formation in pseudomonine biosynthesis J Am Chem Soc 130 12282-4. Morii H, Kasama K, Herrera-Espinoza R. (2006) Cloning and sequencing of the histidine decarboxylase gene from Photobacterium phosphoreum and its functional expression in Escherichia coli J Food Prot 69 1768-76. Tolmasky, M.E.; Actis, L.A.; Crosa, J.H. (1995) A histidine decarboxylase gene encoded by the Vibrio anguillarum plasmid pJM1 is essential for virulence: histamine is a precursor in the biosynthesis of anguibactin Mol Microbio 15 87-95. Kamath, A.V.; Vaaler, G.L.; Snell, E.E. (1991) Pyridoxal phosphate-dependent histidine decarboxylases. Cloning, sequencing, and expression of genes from Klebsiella planticola and Enterobacter aerogenes and properties of the overexpressed enzymes J Biol Chem 266 9432-7. Vaaler, G. L.; Brasch, M. A.; Snell, E. E. (1986) Pyridoxal 5'-phosphate-dependent histidine decarboxylase. Nucleotide sequence of the hdc gene and the corresponding amino acid sequence J Biol Chem 261 11010-4. Articles on 4.1.1.22.a |
last changed |
2008/01/24 18:18 |
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