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B6db families: 4.1.1.29

4.1.1.29
Activity 4.1.1.29
Description Sulfinoalanine decarboxylase.
Notes The mammalian sequences in this family are strictly related to those of metazoan glutamate decarboxylases (4.1.1.15_a).

Very similar genes found in insects (Drosophila etc.) have not been included here because sulfinoalanine decarboxylase activity has been described only in vertebrates.

PDB 2JIS;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
11
Sequences in seed alignment
MetazoaXP_849310 (Canis familiaris); CSD_RAT (Rattus norvegicus); XP_005695573 (Capra hircus); NP_001246025 (Drosophila melanogaster); NP_082914 (Mus musculus); XP_004588430 (Ochotona princeps); CSD_HUMAN (Homo sapiens); AAI48147 (Bos taurus); NP_476788 (Drosophila melanogaster); XP_001363928 (Monodelphis domestica); XP_005971826 (Pantholops hodgsonii);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence CSD_HUMAN
Domain interval 49-417
Catalytic site 305 K
 
References
 Liu P, Ding H, Christensen BM, Li J. (2012) Cysteine sulfinic acid decarboxylase activity of Aedes aegypti aspartate 1-decarboxylase: the structural basis of its substrate selectivity. Insect Biochem Mol Biol. 42 396-403.

 Liu P, Ge X, Ding H, Jiang H, Christensen BM, Li J. (2012) Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis. J Biol Chem. 287 40898-906.

 Park, E.; Park, S.Y.; Wang, C.; Xu, J.; LaFauci, G.; Schuller-Levis, G. (2002) Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA expression in murine tissues Biochim Biophys Acta 1574 403-06.

 Reymond I, Sergeant A, Tappaz M. (1996) Molecular cloning and sequence analysis of the cDNA encoding rat liver cysteine sulfinate decarboxylase (CSD) Biochim Biophys Acta 1307 152-6.

Articles on 4.1.1.29
last changed 2009/06/30 14:33

B6db families