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B6db families: 4.1.1.29

4.1.1.29
Activity 4.1.1.29
Description Sulfinoalanine decarboxylase
Notes The mammalian sequences in this family are strictly related to those of metazoan glutamate decarboxylases (4.1.1.15_a).

The insect enzymes (e.g., the one from Aedes egypti) also possess a substantial aspartate 1-decarboxylase activity and are often annotated as Aspartate 1-decarboxylases.

PDB 2JIS;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence CSD_HUMAN
Domain interval 49-417
Catalytic site 305 K
 
References
 Liu P, Ding H, Christensen BM, Li J. (2012) Cysteine sulfinic acid decarboxylase activity of Aedes aegypti aspartate 1-decarboxylase: the structural basis of its substrate selectivity. Insect Biochem Mol Biol. 42 396-403.

 Liu P, Ge X, Ding H, Jiang H, Christensen BM, Li J. (2012) Role of glutamate decarboxylase-like protein 1 (GADL1) in taurine biosynthesis. J Biol Chem. 287 40898-906.

 Park, E.; Park, S.Y.; Wang, C.; Xu, J.; LaFauci, G.; Schuller-Levis, G. (2002) Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA expression in murine tissues Biochim Biophys Acta 1574 403-06.

 Reymond I, Sergeant A, Tappaz M. (1996) Molecular cloning and sequence analysis of the cDNA encoding rat liver cysteine sulfinate decarboxylase (CSD) Biochim Biophys Acta 1307 152-6.

Articles on 4.1.1.29
last changed 2018/05/07 13:37

B6db families