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B6db families: 4.1.2.27

4.1.2.27
Activity 4.1.2.27
Description Sphinganine-1-phosphate aldolase.
Notes Compact family of eukaryotic enzymes with regulatory functions.
Similar sequences occur in archaea and some bacteria, but the activity of the gene products is not documented.
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
24
Sequences in seed alignment
FungiNP_010580 (Saccharomyces cerevisiae); EAA56807 (Magnaporthe grisea); CAB91763 (Neurospora crassa); EAK93581 (Candida albicans); XP_384589 (Gibberella zeae); EAA63890 (Aspergillus nidulans);
MetazoaXP_001639902 (Nematostella vectensis); NP_001082938 (Danio rerio); NP_652032 (Drosophila melanogaster); SGP1_RAT (Rattus norvegicus); SGPL_CAEEL (Caenorhabditis elegans); NP_003892 (Homo sapiens); NP_001007947 (Gallus gallus); XP_321361 (Anopheles gambiae); JC5923 (Mus musculus); XP_001607959 (Nasonia vitripennis);
Other_EukaryaEAN95730 (Trypanosoma cruzi); XP_001745715 (Monosiga brevicollis); AAP37027 (Dictyostelium discoideum); XP_001467082 (Leishmania infantum );
ViridiplantaeABK24262 (Picea sitchensis); BAB62623 (Oryza sativa); CAO41624 (Vitis vinifera); NP_174119 (Arabidopsis thaliana);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence NP_003892
Domain interval 150-456
Catalytic site 353 K
 
References
 Li, G.; Foote, C.; Alexander, S.; Alexander, H. (2001) Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum Development 128 3473-83.

 Van Veldhoven, P.P.; Gijsbers, S.; Mannaerts, G.P.; Vermeesch, J.R.; Brys, V. (2000) Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1) Biochim Biophys Acta 1487 128-34.

 Zhou, J.; Saba, J. D. (1998) Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast Biochem Biophys Res Commun 242 502-7.

 Saba, J.D.; Nara F.; Bielawska, A.; Garrett, S.; Hannun, Y.A. (1997) The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem 272 26087-90.

Articles on 4.1.2.27
last changed 2008/02/15 13:51

B6db families