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B6db families: 4.1.2.27

4.1.2.27
Activity 4.1.2.27
Description Sphinganine-1-phosphate aldolase
Notes Compact family of eukaryotic and bacterial enzymes with regulatory functions.
Similar sequences occur in some archaea, but the activity of the gene products is not documented.
PDB 3MAD;3MAF;3MBB;3MAF;5K1R;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence NP_003892
Domain interval 150-456
Catalytic site 353 K
 
References
 McLean CJ, Marles-Wright J, Custodio R, Lowther J, Kennedy AJ, Pollock J, Clarke DJ, Brown AR, Campopiano DJ (2017) Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei J Lipid Res 58 137-150.

 Huwiler A, Bourquin F, Kotelevets N, Pastukhov O, Capitani G, Grütter MG, Zangemeister-Wittke U (2011) A prokaryotic S1P lyase degrades extracellular S1P in vitro and in vivo: implication for treating hyperproliferative disorders PLoS One 6 e22436.

 Li, G.; Foote, C.; Alexander, S.; Alexander, H. (2001) Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum Development 128 3473-83.

 Van Veldhoven, P.P.; Gijsbers, S.; Mannaerts, G.P.; Vermeesch, J.R.; Brys, V. (2000) Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1) Biochim Biophys Acta 1487 128-34.

 Zhou, J.; Saba, J. D. (1998) Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast Biochem Biophys Res Commun 242 502-7.

 Saba, J.D.; Nara F.; Bielawska, A.; Garrett, S.; Hannun, Y.A. (1997) The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem 272 26087-90.

Articles on 4.1.2.27
last changed 2017/11/02 09:49

B6db families