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B6db families: 4.1.99.1

4.1.99.1
Activity 4.1.99.1
Description Tryptophanase.
Notes A group of closely related bacterial sequences, very similar to tyrosine phenol-lyases (family 4.1.99.2). There is evidence for horizontal transfer of this gene between bacterial species.
PDB 1AX4;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
15
Sequences in seed alignment
BacteriaAAO36064.1 (Clostridium tetani E88); TNAA_PROVU (Proteus vulgaris); NP_623202.1 (Thermoanaerobacter tengcongensis); AAS10747 (Treponema denticola); ZP_00098434.1 (Desulfitobacterium hafniense); AAQ58838 (Chromobacterium violaceum); TNA1_SYMTH (Symbiobacterium thermophilum); TNAA_ENTAE (Enterobacter aerogenes); TNAA_VIBPA (Vibrio parahaemolyticus); TNAA_ECOLI (Escherichia coli); TNAA_HAEIN (Haemophilus influenzae); TNAA_PROIN (Proteus inconstans); TNA2_SYMTH (Symbiobacterium thermophilum); TNAA_PHOLL (Photorhabdus luminescens); NP_246359 (Pasteurella multocida);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence TNAA_ECOLI
Domain interval 49-438
Catalytic site 270 K
 
References
 Ku SY, Yip P, Howell PL. (2006) Structure of Escherichia coli tryptophanase Acta Crystallogr D Biol Crystallogr 62 814-23.

 Martin, K.; Morlin, G.; Smith, A.; Nordyke, A.; Eisenstark, A.; Golomb, M. (1998) The tryptophanase gene cluster of Haemophilus influenzae type b: evidence for horizontal gene transfer J Bacteriol 180 107-18.

 Kawasaki K, Yokota A, Tomita F. (1995) Enzymatic synthesis of L-tryptophan by Enterobacter aerogenes tryptophanase highly expressed in Escherichia coli, and some properties of the purified enzyme Biosci Biotechnol Biochem 59 1938-43.

 Hirahara, T.; Suzuki, S.; Horinouchi, S.; Beppu, T. (1992) Cloning, nucleotide sequences, and overexpression in Escherichia coli of tandem copies of a tryptophanase gene in an obligately symbiotic thermophile, Symbiobacterium thermophilum Appl Environ Microbiol 58 2633-42.

 Deeley, M.C.; Yanofsky, C. (1981) Nucleotide sequence of the structural gene for tryptophanase of Escherichia coli K-12 J Bacteriol 147 787-96.

Articles on 4.1.99.1
last changed 2008/01/22 18:37

B6db families