B6db families : 4_1_99

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4.1.99.2

Activity

4.1.99.2

Description

Tyrosine phenol-lyase

Notes

A group of closely related bacterial sequences, very similar to tryptophanases (family 4.1.99.1).

PDB

1TPL;2TPL;

PLP Fold Type

PLP-dependent Domain

Domain alignment
Domain hmm

Fold type I

Number of sequences

Sequences in seed alignment

Bacteria

WP_092070081 (Dendrosporobacter quercicolus); ZP_00109641 (Nostoc punctiforme); WP_012119412 (Roseiflexus castenholzii); AAS11607 (Treponema denticola); WP_014064489 (Haemophilus parainfluenzae); WP_014186642 (Desulfosporosinus orientis); WP_061051598 (Vibrio mimicus); WP_091773697 (Piscibacillus halophilus); WP_084690519 (Comamonas granuli); ZP_00099855 (Desulfitobacterium hafniense); TPL_ERWHE (Erwinia herbicola); WP_004241032 (Morganella morganii); AAK02895 (Pasteurella multocida); WP_084197242 (Paracoccus versutus); TPL_CITFR (Citrobacter freundii); TPL_SYMS1 (Symbiobacterium sp. SC-1); TPL_CLOTE (Clostridium tetani); TPL_FUSNN (Fusobacterium nucleatum);

DISPLAY: Fasta format, alignment, hmm, hmm_local

Reference sequence

TPL_CITFR

Domain interval

46-423

Catalytic site

257 K

References

Zheng RC, Tang XL, Suo H, Feng LL, Liu X, Yang J, Zheng YG (2018) Biochemical characterization of a novel tyrosine phenol-lyase from Fusobacterium nucleatum for highly efficient biosynthesis of l-DOPA Enzyme Microb Technol 112 88-93.

Lee, S. G.; Hong, S. P.; Choi, Y. H.; Chung, Y. J.; Sung, M. H. (1997) Thermostable tyrosine phenol-lyase of Symbiobacterium sp. SC-1: gene cloning, sequence determination, and overproduction in Escherichia coli Protein Expr Purif 11 263-70.

Sundararaju, B.; Antson, A. A.; Phillips, R. S.; Demidkina, T. V.; Barbolina, M. V.; Gollnick, P.; Dodson, G. G.; Wilson, K. S. (1997) The crystal structure of Citrobacter freundii tyrosine phenol-lyase complexed with 3-(4'-hydroxyphenyl)propionic acid, together with site- directed mutagenesis and kinetic analysis, demonstrates that arginine 381 is required for substrate specificity Biochemistry 36 6502-10.

Iwamori, S.; Oikawa, T.; Ishiwata, K.; Makiguchi, N. (1992) Cloning and expression of the Erwinia herbicola tyrosine phenol-lyase gene in Escherichia coli Biotechnol Appl Biochem 16 77-85.

Articles on 4.1.99.2

last changed

2008/01/29 19:54