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4.2.1.122 |
Activity |
4.2.1.122 |
Description |
Tryptophan synthase (indole-salvaging) |
Notes |
The family comprises archaeal, bacterial and plant enzymes. It is strictly related to family 4.2.1.20 (tryptophan synthase, beta subunit).
A distinctive residue of this family is Glu338 (in the S sulfataricus reference sequence, WP_010923209) |
PDB |
4QYS; |
PLP Fold Type |
II |
PLP-dependent Domain |
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Number of sequences |
29 |
Sequences in seed alignment |
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Reference sequence |
WP_010923209 |
Domain interval |
72-413 |
Catalytic site |
111 K |
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References |
Busch F, Rajendran C, Mayans O, Löffler P, Merkl R, Sterner R. (2014) TrpB2 enzymes are O-phospho-l-serine dependent tryptophan synthases Biochemistry 53 6078-83. Hiyama T, Sato T, Imanaka T, Atomi H. (2014) The tryptophan synthase β-subunit paralogs TrpB1 and TrpB2 in Thermococcus kodakarensis are both involved in tryptophan biosynthesis and indole salvage FEBS J 281 3113-25. Yin R, Frey M, Gierl A, Glawischnig E
(2010) Plants contain two distinct classes of functional tryptophan synthase beta proteins Phytochemistry 14-15 1667-72. Hettwer, S.; Sterner, R. (2002) A novel tryptophan synthase beta-subunit from the hyperthermophile Thermotoga maritima. Quaternary structure, steady-state kinetics, and putative physiological role J Biol Chem 277 8194-201. Articles on 4.2.1.122 |
last changed |
2018/01/31 19:22 |
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