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4.2.1.144 |
Activity |
4.2.1.144 |
Description |
3-amino-5-hydroxybenzoic acid synthase |
Notes |
A small, compact family of enzymes from Streptomyces and related, antibiotic-producing bacterial species. |
PDB |
1B9H; |
PLP Fold Type |
I |
PLP-dependent Domain |
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Number of sequences |
8 |
Sequences in seed alignment |
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Reference sequence |
AAC01720 |
Domain interval |
15-382 |
Catalytic site |
188 K |
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References |
He W, Wu L, Gao Q, Du Y, Wang Y.
(2006) Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997 Curr Microbiol 52 197-203. Yu, T.W., Bai, L., Clade, D., Hoffmann, D., Toelzer, S., Trinh, K.Q., Xu, J., Moss, S.J., Leistner, E., Floss, H.G.
(2002) The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum Proc Natl Acad Sci U S A. 99 7968-7973. Eads, J.C., Beeby, M., Scapin, G., Yu, T.W.; Floss, H.G. (1999) Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase Biochemistry 38 9840-9849. Articles on 4.2.1.144 |
last changed |
2014/02/19 11:56 |
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