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B6db families: 4.2.1.144

4.2.1.144
Activity 4.2.1.144
Description 3-amino-5-hydroxybenzoic acid synthase
Notes A small, compact family of enzymes from Streptomyces and related, antibiotic-producing bacterial species.
PDB 1B9H;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
7
Sequences in seed alignment
BacteriaAAL48265 (Kitasatospora sp. F18-97); AAM54102 (Actinosynnema pretiosum subsp. auranticum); AAC13997 (Actinosynnema pretiosum subsp. auranticum); AAD31828 (Streptomyces collinus); AAD32723 (Streptomyces lavendulae); AAL77217 (Streptomyces hygroscopicus); AAC01720 (Amycolatopsis mediterranei);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence AAC01720
Domain interval 15-382
Catalytic site 188 K
 
References
 He W, Wu L, Gao Q, Du Y, Wang Y. (2006) Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997 Curr Microbiol 52 197-203.

 Yu, T.W., Bai, L., Clade, D., Hoffmann, D., Toelzer, S., Trinh, K.Q., Xu, J., Moss, S.J., Leistner, E., Floss, H.G. (2002) The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum Proc Natl Acad Sci U S A. 99 7968-7973.

 Eads, J.C., Beeby, M., Scapin, G., Yu, T.W.; Floss, H.G. (1999) Crystal structure of 3-amino-5-hydroxybenzoic acid (AHBA) synthase Biochemistry 38 9840-9849.

Articles on 4.2.1.144
last changed 2014/02/19 11:56

B6db families