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B6db families: 4.3.1.18.b

4.3.1.18 b
Activity 4.3.1.18
Description D-serine ammonia-lyase. (family b)
Notes A family of fold-type III proteins, built based on the functionally validated sequences from yeast and chicken.
These eukaryotic proteins are more closely related to those of family 4.1.2.85 (D-threonine aldolase, low specificity) than to those of bacterial D-amino acid ammonia-lyases. All three families, however, share the requirement of a divalent metal ion (in addition to PLP) for function.
PLP Fold Type III
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type III

Number of sequences
11
Sequences in seed alignment
FungiNP_011319 (Saccharomyces cerevisiae); XP_455572 (Kluyveromyces lactis); XP_001262434 (Neosartorya fischeri); XP_445494 (Candida glabrata); NP_594997 (Schizosaccharomyces pombe 972h-); XP_462390 (Debaryomyces hansenii); XP_001483903 (Pichia guilliermondii); XP_001383278 (Pichia stipitis);
MetazoaAAI22307 (Danio rerio); XP_002127262 (Ciona intestinalis); BAF95910 (Gallus gallus);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence NP_011319
Domain interval 8-325
Catalytic site 60 K
 
References
 Ito T, Hemmi H, Kataoka K, Mukai Y, Yoshimura T. (2008) A novel zinc-dependent D-serine dehydratase from Saccharomyces cerevisiae Biochem J 409 399-406.

 Tanaka H, Yamamoto A, Ishida T, Horiike K. (2008) D-Serine dehydratase from chicken kidney: a vertebral homologue of the cryptic enzyme from Burkholderia cepacia J Biochem 143 49-57.

Articles on 4.3.1.18.b
last changed 2011/02/07 12:16

B6db families