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B6db families: 4.4.1.11

4.4.1.11
Activity 4.4.1.11
Description Methionine gamma-lyase
Notes A family composed of bacterial, plant and protozoan sequences, strictly related to (and difficult to distinguish from) cystathionine gamma lyase (family 4.4.1.1) and other families of PLP-dependent enzymes acting on sulfurated amino acids.
PDB 1GC0;1E5F;5DX5;4U1T;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
32
Sequences in seed alignment
BacteriaNP_783053 (Clostridium tetani); WP_093409492 (Verrucosispora sediminis); MEGL_PSEPU (Pseudomonas putida); NP_904655 (Porphyromonas gingivalis W83); ADI48596 (Idiomarina sp.); NP_972801 (Treponema denticola); ZP_00043129 (Magnetococcus sp. MC-1); AAK25130 (Caulobacter crescentus CB15); WP_010988457 (Streptomyces avermitilis); WP_017463017 (Dyella ginsengisoli); WP_013229485 (Amycolatopsis mediterranei); ZP_04566687 (Fusobacterium mortiferum); NP_717420 (Shewanella oneidensis ); WP_003482836 (Clostridium sporogenes); AAO46884 (Citrobacter freundii); AMB19000 (Clostridium novyi); AAM94792 (Micromonospora echinospora); NP_604313 (Fusobacterium nucleatum subsp. nucleatum ATCC 25586); ACB86020 (Natranaerobius thermophilus); WP_028673606 (Salinispora arenicola); ZP_00009970 (Rhodopseudomonas palustris);
MetazoaOHT16919 (Tritrichomonas foetus); CAA04124 (Trichomonas vaginalis); BAC75877 (Entamoeba histolytica); XP_004185777 (Entamoeba invadens IP1); CAA04125 (Trichomonas vaginalis); BAC75878 (Entamoeba histolytica);
ViridiplantaeXP_021856981 (Spinacia oleracea); XP_003520012 (Glycine max); MGL_ARATH (Arabidopsis thaliana); XP_012486629 (Gossypium raimondii); NP_001315378 (Cucumis melo);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence MEGL_PSEPU
Domain interval 11-395
Catalytic site 211 K
 
References
 Kulikova VV, Morozova EA, Revtovich SV, Kotlov MI, Anufrieva NV, Bazhulina NP, Raboni S, Faggiano S, Gabellieri E, Cioni P, Belyi YF, Mozzarelli A, Demidkina TV (2017) Gene cloning, characterization, and cytotoxic activity of methionine γ-lyase from Clostridium novyi IUBMB Life 69 668-676.

 Huang KY, Hu HY, Tang YL, Xia FG, Luo XQ, Liu J (2015) High-Level Expression, Purification and Large-Scale Production of l-Methionine γ-Lyase from Idiomarina as a Novel Anti-Leukemic Drug Mar Drugs 13 5492-507.

 Kudou D, Yasuda E, Hirai Y, Tamura T, Inagaki K (2015) Molecular cloning and characterization of l-methionine γ-lyase from Streptomyces avermitilis J Biosci Bioeng 120 380-3.

 Song H, Xu R, Guo Z (2015) Identification and characterization of a methionine γ-lyase in the calicheamicin biosynthetic cluster of Micromonospora echinospora Chembiochem 16 100-9.

 Gonda I, Lev S, Bar E, Sikron N, Portnoy V, Davidovich-Rikanati R, Burger J, Schaffer AA, Tadmor Y, Giovannonni JJ, Huang M, Fei Z, Katzir N, Fait A, Lewinsohn E (2013) Catabolism of L-methionine in the formation of sulfur and other volatiles in melon (Cucumis melo L.) fruit Plant J 74 458-72.

 Morozova EA, Kulikova VV, Yashin DV, Anufrieva NV, Anisimova NY, Revtovich SV, Kotlov MI, Belyi YF, Pokrovsky VS, Demidkina TV (2013) Kinetic Parameters and Cytotoxic Activity of Recombinant Methionine γ-Lyase from Clostridium tetani, Clostridium sporogenes, Porphyromonas gingivalis and Citrobacter freundii Acta Naturae 5 92-8.

 Revtovich SV, Morozova EA, Anufrieva NV, Kotlov MI, Belyi YF, Demidkina TV (2012) Identification of methionine γ-lyase in genomes of some pathogenic bacteria Dokl Biochem Biophys 445 187-93.

 Suwabe K, Yoshida Y, Nagano K, Yoshimura F. (2011) Identification of an L-methionine γ-lyase involved in the production of hydrogen sulfide from L-cysteine in Fusobacterium nucleatum subsp. nucleatum ATCC 25586 Microbiology 157 2992-3000.

 Goyer A, Collakova E, Shachar-Hill Y, Hanson AD (2007) Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway Plant Cell Physiol 48 232-42.

 Fukamachi, H.; Nakano, Y.; Okano, S.; Shibata, Y.; Abiko, Y.; Yamashita, Y. (2005) High production of methyl mercaptan by L-methionine-alpha-deamino-gamma-mercaptomethane lyase from Treponema denticola Biochem Biophys Res Commun 331 127-31.

 Manukhov, IV, Mamaeva, DV, Rastorguev, SM, Faleev, NG, Morozova, EA, Demidkina, TV, Zavilgelsky, GB. (2005) A gene encoding L-methionine gamma-lyase is present in Enterobacteriaceae family genomes: identification and characterization of Citrobacter freundii L-methionine gamma-lyase J Bacteriol 187 3889-93.

 Tokoro, M.; Asai, T.; Kobayashi, S.; Takeuchi, T.; Nozaki, T. (2003) Identification and characterization of two isoenzymes of methionine gamma-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an anaerobic parasitic protist that lacks forward and reverse trans-sulfuration pathways J Biol Chem 278 42717-27.

 Yoshimura, M.; Nakano, Y.; Yamashita, Y.; Oho, T.; Saito, T.; Koga, T. (2000) Formation of methyl mercaptan from L-methionine by Porphyromonas gingivalis Infect Immun 68 6912-6.

 McKie, A. E.; Edlind, T.; Walker, J.; Mottram, J. C.; Coombs, G. H. (1998) The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes J Biol Chem 273 5549-56.

 Hori H, Takabayashi K, Orvis L, Carson DA, Nobori T. (1996) Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase Cancer Res 56 2116-22.

Articles on 4.4.1.11
last changed 2017/10/03 13:00

B6db families