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B6db families: 4.4.1.11

4.4.1.11
Activity 4.4.1.11
Description Methionine gamma-lyase.
Notes Rather compact family composed of bacterial and protozoan sequences, strictly related to cystathionine gamma lyase (family 4.4.1.1) and other families of PLP-dependent enzymes acting on sulfurated amino acids.
PDB 1GC0;1E5F;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
16
Sequences in seed alignment
BacteriaAAK25130 (Caulobacter crescentus CB15); ZP_04566687 (Fusobacterium mortiferum); ZP_00009970 (Rhodopseudomonas palustris); NP_604313 (Fusobacterium nucleatum subsp. nucleatum ATCC 25586); NP_717420 (Shewanella oneidensis ); NP_904655 (Porphyromonas gingivalis W83); ACB86020 (Natranaerobius thermophilus); ZP_00043129 (Magnetococcus sp. MC-1); NP_783053 (Clostridium tetani); AAO46884 (Citrobacter freundii); NP_972801 (Treponema denticola); MEGL_PSEPU (Pseudomonas putida);
MetazoaCAA04124 (Trichomonas vaginalis); BAC75877 (Entamoeba histolytica); BAC75878 (Entamoeba histolytica); CAA04125 (Trichomonas vaginalis);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence MEGL_PSEPU
Domain interval 11-395
Catalytic site 211 K
 
References
 Fukamachi, H.; Nakano, Y.; Okano, S.; Shibata, Y.; Abiko, Y.; Yamashita, Y. (2005) High production of methyl mercaptan by L-methionine-alpha-deamino-gamma-mercaptomethane lyase from Treponema denticola Biochem Biophys Res Commun 331 127-31.

 Manukhov, IV, Mamaeva, DV, Rastorguev, SM, Faleev, NG, Morozova, EA, Demidkina, TV, Zavilgelsky, GB. (2005) A gene encoding L-methionine gamma-lyase is present in Enterobacteriaceae family genomes: identification and characterization of Citrobacter freundii L-methionine gamma-lyase J Bacteriol 187 3889-93.

 Tokoro, M.; Asai, T.; Kobayashi, S.; Takeuchi, T.; Nozaki, T. (2003) Identification and characterization of two isoenzymes of methionine gamma-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an anaerobic parasitic protist that lacks forward and reverse trans-sulfuration pathways J Biol Chem 278 42717-27.

 Yoshimura, M.; Nakano, Y.; Yamashita, Y.; Oho, T.; Saito, T.; Koga, T. (2000) Formation of methyl mercaptan from L-methionine by Porphyromonas gingivalis Infect Immun 68 6912-6.

 McKie, A. E.; Edlind, T.; Walker, J.; Mottram, J. C.; Coombs, G. H. (1998) The primitive protozoon Trichomonas vaginalis contains two methionine gamma-lyase genes that encode members of the gamma-family of pyridoxal 5'-phosphate-dependent enzymes J Biol Chem 273 5549-56.

 Hori H, Takabayashi K, Orvis L, Carson DA, Nobori T. (1996) Gene cloning and characterization of Pseudomonas putida L-methionine-alpha-deamino-gamma-mercaptomethane-lyase Cancer Res 56 2116-22.

Articles on 4.4.1.11
last changed 2008/06/09 19:39

B6db families