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B6db families: 4.4.1.15

4.4.1.15
Activity 4.4.1.15
Description D-cysteine desulfhydrase
Notes A family of bacterial and plant enzymes, strictly related to L-cysteate sulfo-lyases (EC 4.4.1.25) and to 1-aminocyclopropane-1-carboxylate deaminase (EC 3.5.99.7).

Ser/Thr288 and Thr315 (numbering after the reference sequence from E. coli; the corresponding residues in the Solanum lycopersicon enzyme are Ser358 and Thr386, respectively) have been described by Todorovic and Glick as distinctive residues.

PDB 4D9F;
PLP Fold Type II
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type II

Number of sequences
14
Sequences in seed alignment
BacteriaZP_00086474 (Pseudomonas fluorescens PfO-1); CAD05702 (Salmonella enterica subsp. enterica serovar Typhi); DCYD_ECOLI (Escherichia coli); NP_794910 (Pseudomonas syringae ); NP_460906 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2); WP_091712747 (Methylobacterium phyllostachyos); ACS40143 (Methylorubrum extorquens AM1); CAC90662 (Yersinia pestis);
ViridiplantaeXP_015626189 (Oryza sativa Japonica Group); RWR75146 (Cinnamomum micranthum f. kanehirae); NP_175275 (Arabidopsis thaliana); XP_016563957 (Capsicum annuum); ACC95419 (Solanum lycopersicon); CAO68552 (Vitis vinifera);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence DCYD_ECOLI
Domain interval 12-316
Catalytic site 51 K
 
References
 Zhou H, Guan W, Zhou M, Shen J, Liu X, Wu D, Yin X, Xie Y (2020) Cloning and Characterization of a gene Encoding True D-cysteine Desulfhydrase from Oryza sativa Plant Mol Biol Rep 38 95113.

 Ekimova GA, Fedorov DN, Tani A, Doronina NV, Trotsenko YA (2018) Distribution of 1-aminocyclopropane-1-carboxylate deaminase and D-cysteine desulfhydrase genes among type species of the genus Methylobacterium Antonie Van Leeuwenhoek 111 1723-1734.

 Bharath SR, Bisht S, Harijan RK, Savithri HS, Murthy MR (2012) Structural and mutational studies on substrate specificity and catalysis of Salmonella typhimurium D-cysteine desulfhydrase PLoS One 7 e36267.

 Todorovic B, Glick BR (2008) The interconversion of ACC deaminase and D-cysteine desulfhydrase by directed mutagenesis Planta 229 193-205.

 Riemenschneider, A.; Wegele, R.; Schmidt, A.; Papenbrock, J. (2005) Isolation and characterization of a D-cysteine desulfhydrase protein from Arabidopsis thaliana FEBS J 272 1291-1304.

 Soutourina, J.; Blanquet, S.; Plateau, P. (2001) Role of D-cysteine desulfhydrase in the adaptation of Escherichia coli to D-cysteine J Biol Chem 276 40864-72.

Articles on 4.4.1.15
last changed 2020/02/21 10:27

B6db families