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B6db families: 4.4.1.16.a

4.4.1.16 a
Activity 4.4.1.16
Description Selenocysteine lyase. (family a)
Notes A family of bacterial and plant enzymes, built around the validated sequences from A. thaliana and E. coli.
In E. coli, the CsdA enzyme is apparently a promiscuous enzyme, with selenocysteine lyase, cisteine desulfurase and cysteine sulfinate desulfinase activities.
PDB 1JF9;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
28
Sequences in seed alignment
ArchaeaCSD_AERPE (Aeropyrum pernix); NP_577893 (Pyrococcus furiosus DSM 3638); YP_003130137 (Halorhabdus utahensis DSM 12940); CBI67620 (Haloferax volcanii DS2);
BacteriaAAL52220 (Brucella melitensis); CAE06837 (Synechococcus sp.); CSDB_ECOLI (Escherichia coli); CAE14992 (Photorhabdus luminescens); NP_924319 (Gloeobacter violaceus); ZP_01978641 (Vibrio Cholerae); YP_003005481 (Dickeya zeae Ech1591); BAC24503 (Wigglesworthia glossinidia); CSDA_ECOLI (Escherichia coli); AAM25789 (Thermoanaerobacter tengcongensis); NP_349885 (Clostridium acetobutylicum); NP_653448 (Bacillus anthracis A2012); NP_465936 (Listeria monocytogenes EGD-e); CAE27908 (Rhodopseudomonas palustris); ZP_00072086 (Trichodesmium erythraeum IMS101); CAE18529 (Prochlorococcus marinus); CAC91205 (Yersinia pestis); NP_460338 (Salmonella typhimurium LT2);
ViridiplantaeAAL14994 (Arabidopsis thaliana); ABK25420 (Picea sitchensis); XP_002314018 (Populus trichocarpa); ACO61177 (Micromonas sp. RCC299); CAO67306 (Vitis vinifera); XP_001755047 (Physcomitrella patens);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence CSDB_ECOLI
Domain interval 25-394
Catalytic site 226 K
 
References
 Zafrilla B, Martínez-Espinosa RM, Esclapez J, Pérez-Pomares F, Bonete MJ. (2010) SufS protein from Haloferax volcanii involved in Fe-S cluster assembly in haloarchaea Biochim Biophys Acta 1804 1476-82 .

 Pilon-Smits EA, Garifullina GF, Abdel-Ghany S, Kato S, Mihara, H., Hale, K.L., Burkhead, J.L., Esaki, N., Kurihara, T., Pilon, M. (2002) Characterization of a NifS-like chloroplast protein from Arabidopsis. Implications for its role in sulfur and selenium metabolism Plant Physiol 130 1309-18.

 Mihara, H.; Maeda, M.; Fujii, T.; Kurihara, T.; Hata, Y.; Esaki, N. (1999) A nifS-like gene, csdB, encodes an Escherichia coli counterpart of mammalian selenocysteine lyase. Gene cloning, purification, characterization and preliminary x-ray crystallographic studies J Biol Chem 274 14768-72.

 Mihara, H.; Kurihara, T.; Yoshimura, T.; Soda, K.; Esaki, N. (1997) Cysteine sulfinate desulfinase, a NIFS-like protein of Escherichia coli with selenocysteine lyase and cysteine desulfurase activities. Gene cloning, purification, and characterization of a novel pyridoxal enzyme J Biol Chem 272 22417-24.

Articles on 4.4.1.16.a
last changed 2009/07/22 10:21

B6db families