Activities | Families | Sequences | Fold types | References | Help
B6db families: a
Description L-cysteine desulfidase (family a)
Notes All the characterized enzymes in this family also show cystathionine beta-lyase activity (E.C. and sometimes methionine gamma-lyase activity (
Indeed, the family is tightly related to families and, with which it forms a 'supercluster' of C-S lyase enzymes.
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence PATB_BACSU
Domain interval 27-382
Catalytic site 234 K
  Allegrini A, Astegno A, La Verde V, Dominici P. (2017) Characterization of C-S lyase from Lactobacillus delbrueckii subsp. bulgaricus ATCC BAA-365 and its potential role in food flavour applications J Biochem 161 49-360.

 Yano T, Fukamachi H, Yamamoto M, Igarashi T. (2009) Characterization of L-cysteine desulfhydrase from Prevotella intermedia Oral Microbiol Immunol 24 485-92.

 Martínez-Cuesta MC, Peláez C, Eagles J, Gasson MJ, Requena T, Hanniffy SB. (2006) YtjE from Lactococcus lactis IL1403 Is a C-S lyase with alpha, gamma-elimination activity toward methionine. Appl Environ Microbiol 72 4878-84.

 Auger, S.; Gomez, M.P.; Danchin, A.; Martin-Verstraete, I. (2005) The PatB protein of Bacillus subtilis is a C-S-lyase Biochimie 87 231-238.

 Wada, M., Awano, N., Haisa, K., Takagi, H., Nakamori, S. (2002) Purification, characterization and identification of cysteine desulfhydrase of Corynebacterium glutamicum, and its relationship to cysteine production FEMS Microbiol Lett 217 103-107.

 Krupka HI, Huber R, Holt SC, Clausen T. (2000) Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5'-phosphate-dependent protein acting as a haemolytic enzyme EMBO J 19 3168-78.

 Chu, L.; Ebersole, J. L.; Kurzban, G. P.; Holt, S. C. (1999) Cystalysin, a 46-kDa L-cysteine desulfhydrase from Treponema denticola: biochemical and biophysical characterization Clin Infect Dis 28 442-50.

 Rossol, I.; Puhler, A. (1992) The Corynebacterium glutamicum aecD gene encodes a C-S lyase with alpha, beta-elimination activity that degrades aminoethylcysteine J Bacteriol 174 2968-77.

Articles on
last changed 2017/09/08 10:07

B6db families