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B6db families: 5.1.1.13.a

5.1.1.13 a
Activity 5.1.1.13
Description Aspartate racemase (family a)
Notes Sequences very similar to those of mammalian serine racemases. Also related, but phylogenetically distinct, from those in family 5.1.1.13b.

Distinctive residues of this family are three consecutive serines (in the Saccoglossus kowalevskii reference sequence, XP_002735975, residues 193-195).
The enzyme with accession number XP_002736011 contains an SAS (rather than SSS) sequence and show similar racemase activities with aspartate and glutamate.

PLP Fold Type II
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type II

Reference sequence XP_002735975
Domain interval 59-355
Catalytic site 97 K
 
References
 Uda K, Ishizuka N, Edashige Y, Kikuchi A, Radkov AD, Moe LA (2019) Cloning and characterization of a novel aspartate/glutamate racemase from the acorn worm Saccoglossus kowalevskii Comp Biochem Physiol B Biochem Mol Biol 232 :87-92.

 Uda K, Abe K, Dehara Y, Mizobata K, Sogawa N, Akagi Y, Saigan M, Radkov AD, Moe LA. (2016) Distribution and evolution of the serine/aspartate racemase family in invertebrates Amino Acids 48 387-402.

Articles on 5.1.1.13.a
last changed 2019/05/31 11:47

B6db families