Activities | Families | Sequences | Fold types | References | Help
B6db families: 5.4.3.4

5.4.3.4
Activity 5.4.3.4
Description D-lysine 5,6-aminomutase.
Notes Lysine 5,6-aminomutase, an adenosylcobalamin and pyridoxal-5'-phosphate-dependent enzyme, is made of two subunits.
PLP is inserted in the TIM-like barrel of the alfa subunit, but is covalently bound to a Lys residue of the Rossmann domain of the beta subunit.

Only sequences of the alfa subunit have been included in this family.

PDB 1XRS;
PLP Fold Type VI
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type VI

Number of sequences
7
Sequences in seed alignment
BacteriaEDK88773 (Fusobacterium nucleatum); BAD39022 (Symbiobacterium thermophilum); AAC79717 (Clostridium sticklandii); NP_622384 (Thermoanaerobacter tengcongensis); YP_001409727 (Fervidobacterium nodosum Rt17-B1); ABW17983 (Alkaliphilus oremlandii OhILAs); AAQ66187 (Porphyromonas gingivalis);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence AAC79717
Domain interval 151-437
Catalytic site n/a
 
References
 Berkovitch, F.; Behshad, E.; Tang, K.H.; Enns, E.A.; Frey, P.A.; Drennan, C.L. (2004) A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase Proc Natl Acad Sci U S A 101 15870-5.

 Tang, K. H.; Harms, A.; Frey, P. A. (2002) Identification of a novel pyridoxal 5'-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis Biochemistry 41 8767-76.

Articles on 5.4.3.4
last changed 2009/07/03 15:03

B6db families