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B6db families:
Description D-lysine 5,6-aminomutase
Notes Lysine 5,6-aminomutase, an adenosylcobalamin and pyridoxal-5'-phosphate-dependent enzyme, is made of two subunits.
PLP is inserted in the TIM-like barrel of the alfa subunit, but is covalently bound to a Lys residue of the Rossmann domain of the beta subunit.

Only sequences of the alfa subunit have been included in this family.

PLP Fold Type VI
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type VI

Reference sequence AAC79717
Domain interval 151-437
Catalytic site n/a
 Berkovitch, F.; Behshad, E.; Tang, K.H.; Enns, E.A.; Frey, P.A.; Drennan, C.L. (2004) A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase Proc Natl Acad Sci U S A 101 15870-5.

 Tang, K. H.; Harms, A.; Frey, P. A. (2002) Identification of a novel pyridoxal 5'-phosphate binding site in adenosylcobalamin-dependent lysine 5,6-aminomutase from Porphyromonas gingivalis Biochemistry 41 8767-76.

Articles on
last changed 2009/07/03 15:03

B6db families