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B6db families: 1.4.4.2

1.4.4.2
Activity 1.4.4.2
Description Glycine dehydrogenase (decarboxylating).
Notes In some organisms, the protein has two distinct subunits. See for example:
gi|14591729|ref|NP_143817.1| glycine dehydrogenase subunit 1 [Pyrococcus horikoshii]
gi|14591728|ref|NP_143816.1| glycine dehydrogenase subunit 2 [Pyrococcus horikoshii].

The two subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence. Only the second subunit, corresponding to the C-terminal half of the multi-domain proteins in known to bind the PLP.

PDB 1WYU;4LHD;
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Number of sequences
30
Sequences in seed alignment
ArchaeaNP_143816 (Pyrococcus horikoshii); NP_342409 (Sulfolobus solfataricus);
BacteriaGCSB_THET2 (Thermus thermophilus); NP_867901 (Pirellula sp.); 4LHD (Synechocystis sp. PCC 6803 substr. Kazusa); GCSP_ECOLI (Escherichia coli); AB0111 (Yersinia pestis); NP_422146 (Caulobacter crescentus); D81821 (Neisseria meningitidis (serogroup A)); GCSP_MYCTU (Mycobacterium tuberculosis); AAK73853 (Brucella abortus); NP_461969 (Salmonella typhimurium); ZP_00162707 (Anabaena variabilis); GCS2_BACSU (Bacillus subtilis); GCSP_SYNY3 (Synechocystis sp. PCC 6803); NP_951437 (Geobacter sulfurreducens); NP_840694 (Nitrosomonas europaea);
FungiGCSP_YEAST (Saccharomyces cerevisiae); EAK92665 (Candida albicans); GCSP_SCHPO (Schizosaccharomyces pombe);
MetazoaNP_649989 (Drosophila melanogaster); GCSP_HUMAN (Homo sapiens); CAE59244 (Caenorhabditis briggsae); CAG08109 (Tetraodon nigroviridis); AAH42245 (Xenopus laevis); GCSP_CHICK (Gallus gallus);
ViridiplantaeGCSP_ARATH (Arabidopsis thaliana); GCSP_SOLTU (Solanum tuberosum); GCSA_FLAPR (Flaveria pringlei); GCSP_PEA (Pisum sativum);

DISPLAY: Fasta format, alignment, hmm, hmm_local


Reference sequence GCSP_CHICK
Domain interval 540-934
Catalytic site 738 K
 
References
 Hasse D.; Mikkat S.; Thrun H.A.; Hagemann, M.; Bauwe, H. (2007) Properties of recombinant glycine decarboxylase P- and H-protein subunits from the cyanobacterium Synechocystis sp. strain PCC 6803. FEBS Lett 581 1297-301.

 Nakai T, Nakagawa N, Maoka N, Masui R, Kuramitsu S, Kamiya N. (2005) Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia EMBO J 24 1523-1536.

 Turner, S.R.; Ireland, R.; Rawsthorne, S. (1992) Cloning and characterization of the P subunit of glycine decarboxylase from pea (Pisum sativum) J Biol Chem 267 5355-60.

 Fujiwara, K.; Okamura-Ikeda, K.; Motokawa, Y. (1987) Amino acid sequence of the phosphopyridoxyl peptide from P-protein of the chicken liver glycine cleavage system Biochem Biophys Res Commun 149 621-7.

Articles on 1.4.4.2
last changed 2014/03/04 10:25

B6db families