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B6db families:
Description Glycine hydroxymethyltransferase
Notes Very distinct family of PLP enzymes, diffused in the three kingdoms of life.
In eukarya, the mitochondrial isozymes are more similar to the cytosolic isozymes than they are to hydroxymethyltransferases from bacteria and archaea.
PLP Fold Type I
PLP-dependent Domain
Domain alignment
Domain hmm
Fold type I

Reference sequence GLYA_ECOLI
Domain interval 8-386
Catalytic site 229 K
 Sodolescu A, Dian C, Terradot L, Bouzhir-Sima L, Lestini R1, Myllykallio H, Skouloubris S, Liebl U. (2018) Structural and functional insight into serine hydroxymethyltransferase from Helicobacter pylori PLoS One 13 e0208850.

 Huang J, Chen L, Hu J, Jiang W, Wu G, Liu Z. (2015) Characterization of a novel serine hydroxymethyltransferase isolated from marine bacterium Arthrobacter sp. and its application on L-serine production Ann Microbiol 65 168998.

 Jiang W, Xia B, Liu Z. (2013) A serine hydroxymethyltransferase from marine bacterium Shewanella algae: Isolation, purification, characterization and l-serine production Microbiol Res 168 477-84.

 Wei Jiang, Bingzhao Xia, Junjie Huang and Ziduo Liu (2013) Characterization of a serine hydroxymethyltransferase for l-serine enzymatic production from Pseudomonas plecoglossicida World Journal of Microbiology and Biotechnology 29 2067-2076.

 Liu S, Kandoth PK, Warren SD, Yeckel G, Heinz R, Alden J, Yang C, Jamai A, El-Mellouki T, Juvale PS, Hill J, Baum TJ, Cianzio S, Whitham SA, Korkin D, Mitchum MG, Meksem K. (2012) A soybean cyst nematode resistance gene points to a new mechanism of plant resistance to pathogens. Nature 492 256-60.

 Waditee-Sirisattha R1, Sittipol D, Tanaka Y, Takabe T. (2012) Overexpression of serine hydroxymethyltransferase from halotolerant cyanobacterium in Escherichia coli results in increased accumulation of choline precursors and enhanced salinity tolerance FEMS Microbiol Lett. 333 46-53.

 Shen P, Chao H, Jiang C, Long Z, Wang C, Wu B. (2010) Enhancing production of L-serine by increasing the glyA gene expression in Methylobacterium sp. MB200 Appl Biochem Biotechnol. 160 740-50.

 Sopitthummakhun K, Maenpuen S, Yuthavong Y, Leartsakulpanich U, Chaiyen P. (2009) Serine hydroxymethyltransferase from Plasmodium vivax is different in substrate specificity from its homologues FEBS J. 276 4023-36.

 Vatsyayan, R.; Roy, U. (2007) Molecular cloning and biochemical characterization of Leishmania donovani serine hydroxymethyltransferase Protein Expr Purif. 52 433-40.

 Mukherjee M, Sievers SA, Brown MT, Johnson PJ. (2006) Identification and biochemical characterization of serine hydroxymethyl transferase in the hydrogenosome of Trichomonas vaginalis Eukaryot Cell 5 2072-8.

 Angelaccio S, Chiaraluce R, Consalvi V, Buchenau B, Giangiacomo L, Bossa F, Contestabile R. (2003) Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii J Biol Chem 278 41789-97.

 Chaturvedi S, Bhakuni V. (2003) Unusual structural, functional, and stability properties of serine hydroxymethyltransferase from Mycobacterium tuberculosis J Biol Chem 278 40793-805.

 Trivedi, V.; Gupta, A.; Jala, V. R.; Saravanan, P.; Rao, G. S.; Rao, N. A.; Savithri, H. S.; Subramanya, H. S. (2002) Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism J Biol Chem 277 17161-9.

 Scarsdale, J. N.; Radaev, S.; Kazanina, G.; Schirch, V.; Wright, H. T. (2000) Crystal structure at 2.4 A resolution of E. coli serine hydroxymethyltransferase in complex with glycine substrate and 5-formyl tetrahydrofolate J Mol Biol 296 155-68.

 Szebenyi, D. M.; Liu, X.; Kriksunov, I. A.; Stover, P. J.; Thiel, D. J. (2000) Structure of a murine cytoplasmic serine hydroxymethyltransferase quinonoid ternary complex: evidence for asymmetric obligate dimers Biochemistry 39 13313-23.

 Scarsdale, J. N.; Kazanina, G.; Radaev, S.; Schirch, V.; Wright, H. T. (1999) Crystal structure of rabbit cytosolic serine hydroxymethyltransferase at 2.8 A resolution: mechanistic implications Biochemistry 38 8347-58.

 Delle Fratte, S.; White, R. H.; Maras, B.; Bossa, F.; Schirch, V. (1997) Purification and properties of serine hydroxymethyltransferase from Sulfolobus solfataricus J Bacteriol 179 7456-61.

 Jagath-Reddy, J.; Ganesan, K.; Savithri, H. S.; Datta, A.; Rao, N. A. (1995) cDNA cloning, overexpression in Escherichia coli, purification and characterization of sheep liver cytosolic serine hydroxymethyltransferase Eur J Biochem 230 533-7.

 Kruschwitz, H.; Ren, S.; Di Salvo, M.; Schirch, V. (1995) Expression, purification, and characterization of human cytosolic serine hydroxymethyltransferase Protein Expr Purif 6 411-6.

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B6db families